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tdk tdk tmk tmk PAE0794 PAE0794 thyX thyX PAE3111 PAE3111 surE1 surE1 PAE1752 PAE1752 surE2 surE2 PAE2452 PAE2452 pyrG pyrG PAE2454 PAE2454
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
tdkThymidine kinase; Purines, pyrimidines, nucleosides, and nucleotides; Nucleotide and nucleoside interconversions. (185 aa)    
Predicted Functional Partners:
tmk
Thymidylate kinase (tmk); Purines, pyrimidines, nucleosides, and nucleotides; Nucleotide and nucleoside interconversions.
  
 
 0.955
PAE0794
Cytidine deaminase; Purines, pyrimidines, nucleosides, and nucleotides; Pyrimidine ribonucleotide biosynthesis.
    
 0.946
thyX
Conserved hypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
    
 0.930
PAE3111
Uridine phosphorylase; Purines, pyrimidines, nucleosides, and nucleotides; Salvage of nucleosides and nucleotides.
    
 0.920
surE1
surE stationary-phase survival protein homolog; Nucleotidase that shows the greatest phosphatase activity on purine (deoxy)nucleoside 5'-monophosphates, particularly the substrates 5'-GMP, 5'-AMP and 2'-deoxy-5'-AMP; Belongs to the SurE nucleotidase family.
  
  
  0.912
PAE1752
Hypothetical protein.
     
  0.900
surE2
surE stationary-phase survival protein homolog; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
  0.900
PAE2452
paREP13; Hypothetical; Conserved within genome.
       0.773
pyrG
CTP synthase (pyrG); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
  
  
 0.763
PAE2454
Conserved hypothetical protein.
       0.740
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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