STRINGSTRING
wtpA wtpA wtpB wtpB wtpC wtpC PF0740 PF0740 eif2g eif2g moaC moaC eIF1A eIF1A PF2025 PF2025 pgk2 pgk2 cpgS cpgS PF1007 PF1007
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
wtpAHypothetical protein; Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Binds tungstate and molybdate, with a preference for tungstate. (345 aa)    
Predicted Functional Partners:
wtpB
Sulfate/thiosulfate transport protein homolog cyst; Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Probably responsible for the translocation of the substrate across the membrane.
 
 0.997
wtpC
Membrane protein; Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Probably responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Sulfate/tungstate importer (TC 3.A.1.6) family.
 
  
  0.968
PF0740
Heavy-metal transporting cpx-type atpase; Function Code: 14.5 Transport and Binding Proteins: Cations.
     
 0.688
eif2g
Translation initiation factor eIF-2, subunit gamma; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
  
   
 0.663
moaC
Molybdenum cofactor biosynthesis protein; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family.
     
 0.649
eIF1A
Translation initiation factor eIF-1a; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.
      
 0.618
PF2025
Hypothetical protein; Function Code: 16.1 Conserved Hypothetical.
 
  
 0.569
pgk2
2-phosphoglycerate kinase; Function Code: 15.1 Other Categories: Adaptations to atypical conditions.
     
 0.552
cpgS
Cyclic 2,3-diphospoglycerate-synthetase; Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP.
       0.548
PF1007
Phosphate transport system permease psta; Function Code: 14.3 Transport and Binding Proteins: Anions.
     
 0.529
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.