node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PF0482 | PF0564 | PF0482 | PF0564 | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | ATP-dependent RNA helicase hepa, putative; Function Code: 12.3 Transcription: RNA processing. | 0.458 |
PF0482 | fen | PF0482 | PF1414 | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.930 |
PF0482 | lig | PF0482 | PF1635 | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | DNA ligase (lig); DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.610 |
PF0482 | pcn | PF0482 | PF0983 | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | Pcna sliding clamp (proliferating-cell nuclear antigen); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. Unlike its eukaryotic paralog, loads on circular DNA without the replication factor C (RFC) clamp loader, although RFC greatly increases loading efficiency. Stimulates the ATPase activity of replication factor C (RFC) in the presence of ssDNA. Stimulates the helicase activity of Hel308 and may alter its substrate specificity. | 0.951 |
PF0482 | pol | PF0482 | PF0212 | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' exonuclease activity. | 0.976 |
PF0482 | polB | PF0482 | PF0018 | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | DNA polymerase II subunit 1; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. | 0.742 |
PF0482 | rfcS | PF0482 | PF0093 | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | Replication factor C, small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. The complex possesses DNA-dependent ATPase activity which is further stimulated by PCNA. Belongs to the activator 1 small subunits family. RfcS subfamily. | 0.946 |
PF0482 | rnhB | PF0482 | PF1781 | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | RNaseH II; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.569 |
PF0564 | PF0482 | PF0564 | PF0482 | ATP-dependent RNA helicase hepa, putative; Function Code: 12.3 Transcription: RNA processing. | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | 0.458 |
PF0564 | fen | PF0564 | PF1414 | ATP-dependent RNA helicase hepa, putative; Function Code: 12.3 Transcription: RNA processing. | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | 0.983 |
PF0564 | lig | PF0564 | PF1635 | ATP-dependent RNA helicase hepa, putative; Function Code: 12.3 Transcription: RNA processing. | DNA ligase (lig); DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.539 |
PF0564 | mre11 | PF0564 | PF1166 | ATP-dependent RNA helicase hepa, putative; Function Code: 12.3 Transcription: RNA processing. | Exonuclease putative; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. | 0.749 |
PF0564 | pcn | PF0564 | PF0983 | ATP-dependent RNA helicase hepa, putative; Function Code: 12.3 Transcription: RNA processing. | Pcna sliding clamp (proliferating-cell nuclear antigen); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. Unlike its eukaryotic paralog, loads on circular DNA without the replication factor C (RFC) clamp loader, although RFC greatly increases loading efficiency. Stimulates the ATPase activity of replication factor C (RFC) in the presence of ssDNA. Stimulates the helicase activity of Hel308 and may alter its substrate specificity. | 0.833 |
PF0564 | pol | PF0564 | PF0212 | ATP-dependent RNA helicase hepa, putative; Function Code: 12.3 Transcription: RNA processing. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' exonuclease activity. | 0.810 |
PF0564 | rad50 | PF0564 | PF1167 | ATP-dependent RNA helicase hepa, putative; Function Code: 12.3 Transcription: RNA processing. | Smc-like protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex. The ATP-bound conformation promotes DNA end binding and end tethering, and alters Mre11 nuclease activity. ATP hydrolysis promotes both Mre11 activity as well as HerA/NurA activity. Has also reversible adenylate kina [...] | 0.657 |
PF0564 | rfcS | PF0564 | PF0093 | ATP-dependent RNA helicase hepa, putative; Function Code: 12.3 Transcription: RNA processing. | Replication factor C, small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. The complex possesses DNA-dependent ATPase activity which is further stimulated by PCNA. Belongs to the activator 1 small subunits family. RfcS subfamily. | 0.464 |
fen | PF0482 | PF1414 | PF0482 | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | Function Code: 4.2 Cellular Processes: Cell division; (cdc21); Belongs to the MCM family. | 0.930 |
fen | PF0564 | PF1414 | PF0564 | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | ATP-dependent RNA helicase hepa, putative; Function Code: 12.3 Transcription: RNA processing. | 0.983 |
fen | lig | PF1414 | PF1635 | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | DNA ligase (lig); DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.972 |
fen | mre11 | PF1414 | PF1166 | Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] | Exonuclease putative; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. | 0.976 |