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purO purO purP purP guaB guaB purA purA surE surE porB_1 porB_1 porA_1 porA_1 MK0084 MK0084 ttdA ttdA fumA fumA porG_1 porG_1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
purOIMP cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. (198 aa)    
Predicted Functional Partners:
purP
Predicted ATP-utilizing enzyme of the ATP-grasp superfamily (probably carboligase); Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family.
 
  
 0.952
guaB
IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
  
 0.932
purA
Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
     
 0.904
surE
Predicted acid phosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
  0.900
porB_1
Pyruvate:ferredoxin oxidoreductase, beta subunit.
       0.800
porA_1
Pyruvate:ferredoxin oxidoreductase, alpha subunit.
  
    0.798
MK0084
Fe-S-cluster-containing hydrogenase component.
       0.773
ttdA
Fumarate hydratase class I, N-terminal domain.
       0.773
fumA
Fumarate hydratase class I, C-terminal domain.
       0.773
porG_1
Pyruvate:ferredoxin oxidoreductase, gamma subunit.
       0.754
Your Current Organism:
Methanopyrus kandleri
NCBI taxonomy Id: 190192
Other names: M. kandleri AV19, Methanopyrus kandleri AV19, Methanopyrus kandleri str. AV19
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