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ftsZ ftsZ ftsA ftsA murG murG mreB mreB mraW mraW recA recA Cj0694 Cj0694 gyrA gyrA atpA atpA Cj1038 Cj1038 murC murC
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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experimentally determined
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textmining
co-expression
protein homology
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ftsZCell division protein FfsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (370 aa)    
Predicted Functional Partners:
ftsA
Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family.
 
 
 0.999
murG
Putative undecaprenyldiphospho-muramoylpentapeptide b-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily.
 
 
 0.956
mreB
Original (2000) note: Cj0276, mreB, homolog of E. coli rod shape-determining protein, len: 346 aa; highly similar to many e.g. MREB_ECOLI rod shape-determining protein mreB (347 aa), fasta scores; opt: 1199 z-score: 1757.3 E(): 0, 55.8% identity in 339 aa overlap. 71.4% identity to HP1373. Contains PS00017 ATP/GTP-binding site motif A (P-loop); Updated (2006) note: Pfam domain PF06723 MreB/Mbl protein was identified within CDS. MreB is known to be a rod shape-determining protein in bacteria and makes up the bacterial cytoskeleton. Further support given to product function. Characterise [...]
  
 
 0.943
mraW
S-adenosyl-methyltransferase; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
   
 0.842
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 
 0.832
Cj0694
Putative periplasmic protein; Original (2000) note: Cj0694, probable periplasmic protein, len: 496 aa; C-terminus is almost identical to C. jejuni ORF TR:Q46115 (EMBL:X95910). 31.9% identity toHP0977. Contains probable N-terminal signal sequence; Updated (2006) note: Literature search identified paper linking product function to glycoprotein. Functional classification - Miscellaneous periplasmic proteins; PMID:12186869.
  
 
 0.825
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
  
 
 0.778
atpA
ATP synthase F1 sector alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family.
   
  
 0.761
Cj1038
Original (2000) note: Cj1038, probable cell division/peptidoglycan biosynthesis protein, len: 387 aa; similar to members of the FTSW/RODA/SPOVE family e.g. RODA_ECOLi rod shape-determining protein RODA (370 aa),fasta scores; opt: 297 z-score: 358.2 E(): 1.2e-12, 27.1% identity in 388 aa overlap, and FTSW_ECOLI cell division protein FTSW (414 aa), fasta scores; opt: 288 z-score: 346.8 E(): 5.1e-12, 28.4% identity in 394 aa overlap. 46.4% identity to HP1560. Contains Pfam match to entry PF01098 FTSW_RODA_SPOVE, Cell cycle protein; Updated (2006) note: Ten probable transmembrane helices p [...]
 
 
 0.755
murC
UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family.
 
 
 0.743
Your Current Organism:
Campylobacter jejuni NCTC 11168
NCBI taxonomy Id: 192222
Other names: C. jejuni subsp. jejuni NCTC 11168 = ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819, Campylobacter jejuni subsp. jejuni ATCC 700819 = NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168, Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
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