node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cj0926 | apt | Cj0926 | Cj0927 | Putative membrane protein; Original (2000) note: Cj0926, possible membrane protein, len: 110 aa; 50.0% identity to HP0573. Contains possible transmembrane domain at N-terminus; Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.909 |
Cj0926 | rpiB | Cj0926 | Cj0925 | Putative membrane protein; Original (2000) note: Cj0926, possible membrane protein, len: 110 aa; 50.0% identity to HP0573. Contains possible transmembrane domain at N-terminus; Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins. | Ribose 5-phosphate isomerase; Original (2000) note: Cj0925, rpiB, probable ribose 5-phosphate isomerase, len: 145 aa; highly similar to e.g. RPIB_ECOLI ribose 5-phosphate isomerase B (EC 5.3.1.6) (149 aa), fasta scores; opt: 399 z-score: 505.9 E(): 7e-21, 45.0% identity in 140 aa overlap. 45.0% identity to HP0574, misannotated as galactosidase acetyltransferase (lacA); Updated (2006) note: Prosite domain PS00237 G_PROTEIN_RECEP_F1_1, Rhodopsin-like GPCR superfamily and Pfam domain PF02502 Ribose/Galactose Isomerase were identified within CDS. Further support given to product function. [...] | 0.802 |
Cj0926 | tyrA | Cj0926 | Cj0130 | Putative membrane protein; Original (2000) note: Cj0926, possible membrane protein, len: 110 aa; 50.0% identity to HP0573. Contains possible transmembrane domain at N-terminus; Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins. | Putative prephenate dehydrogenase; Original (2000) note: Cj0130, tyrA, probable prephenate dehydrogenase, len: 275 aa; similar to e.g. TYRA_BACSU prephenate dehydrogenase (EC 1.3.1.12) (372 aa), fasta scores; opt: 474 z-score: 529.7 E(): 3e-22,31.0% identity in 284 aa overlap. 45.3% identity to HP1380; Updated (2006) note: Characterised within Bacillus subtilis with marginal identity score. Alignment does not cover full sequence length. Putative kept within product function. Functional classification - Amino acid biosynthesis - Aromatic amino acid family; PMID:3106153. | 0.545 |
Cj0926 | ychF | Cj0926 | Cj0930 | Putative membrane protein; Original (2000) note: Cj0926, possible membrane protein, len: 110 aa; 50.0% identity to HP0573. Contains possible transmembrane domain at N-terminus; Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins. | Putative GTP-binding protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. | 0.750 |
apt | Cj0926 | Cj0927 | Cj0926 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Putative membrane protein; Original (2000) note: Cj0926, possible membrane protein, len: 110 aa; 50.0% identity to HP0573. Contains possible transmembrane domain at N-terminus; Updated (2006) note: One probable transmembrane helix predicted by TMHMM2.0. Functional classification -Membranes, lipoproteins and porins. | 0.909 |
apt | gmk | Cj0927 | Cj1177c | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.850 |
apt | guaA | Cj0927 | Cj1248 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.996 |
apt | guaB | Cj0927 | Cj1058c | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.923 |
apt | purB | Cj0927 | Cj0023 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate lyase; Original (2000) note: Cj0023, purB, probable adenylosuccinate lyase, len: 442 aa; similar to e.g. PUR8_BACSU adenylosuccinate lyase (EC 4.3.2.2) (431 aa),fasta scores; opt: 1369 z-score: 2264.2 E(): 0, 49.9% identity in 439 aa overlap. 67.9% identity to HP1112. Contains PS00163 Fumarate lyases signature and Pfam match to entry PF00206 lyase_1, Lyases, score 199.60, E-value 4.7e-56; Updated (2006) note: Characterised within Bacillus subtilis with acceptable identity scores. Thus, putative not added to product function. Functional classification -Purine ribonucleo [...] | 0.836 |
apt | purH | Cj0927 | Cj0953c | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Original (2000) note: Cj0953c, purH,phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase, len: 510 aa; highly similar to many e.g. PUR9_ECOLI phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) / IMP cyclohydrolase (EC 3.5.4.10) (529 aa), fasta scores; opt: 812 z-score: 935.5 E(): 0, 44.6% identity in 529 aa overlap. No Hp match; Updated (2006) note: Pfam domains PF01808 AICARFT/IMPCHase bienzyme and PF02142 MGS-like domain were identified within CDS. Further support given to product function. Characterised in Escherichia coli with acceptabl [...] | 0.810 |
apt | purN | Cj0927 | Cj0187c | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.806 |
apt | rpiB | Cj0927 | Cj0925 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Ribose 5-phosphate isomerase; Original (2000) note: Cj0925, rpiB, probable ribose 5-phosphate isomerase, len: 145 aa; highly similar to e.g. RPIB_ECOLI ribose 5-phosphate isomerase B (EC 5.3.1.6) (149 aa), fasta scores; opt: 399 z-score: 505.9 E(): 7e-21, 45.0% identity in 140 aa overlap. 45.0% identity to HP0574, misannotated as galactosidase acetyltransferase (lacA); Updated (2006) note: Prosite domain PS00237 G_PROTEIN_RECEP_F1_1, Rhodopsin-like GPCR superfamily and Pfam domain PF02502 Ribose/Galactose Isomerase were identified within CDS. Further support given to product function. [...] | 0.804 |
apt | tyrA | Cj0927 | Cj0130 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Putative prephenate dehydrogenase; Original (2000) note: Cj0130, tyrA, probable prephenate dehydrogenase, len: 275 aa; similar to e.g. TYRA_BACSU prephenate dehydrogenase (EC 1.3.1.12) (372 aa), fasta scores; opt: 474 z-score: 529.7 E(): 3e-22,31.0% identity in 284 aa overlap. 45.3% identity to HP1380; Updated (2006) note: Characterised within Bacillus subtilis with marginal identity score. Alignment does not cover full sequence length. Putative kept within product function. Functional classification - Amino acid biosynthesis - Aromatic amino acid family; PMID:3106153. | 0.819 |
apt | ychF | Cj0927 | Cj0930 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Putative GTP-binding protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. | 0.843 |
gmk | apt | Cj1177c | Cj0927 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.850 |
gmk | guaA | Cj1177c | Cj1248 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.972 |
gmk | guaB | Cj1177c | Cj1058c | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.816 |
gmk | purB | Cj1177c | Cj0023 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenylosuccinate lyase; Original (2000) note: Cj0023, purB, probable adenylosuccinate lyase, len: 442 aa; similar to e.g. PUR8_BACSU adenylosuccinate lyase (EC 4.3.2.2) (431 aa),fasta scores; opt: 1369 z-score: 2264.2 E(): 0, 49.9% identity in 439 aa overlap. 67.9% identity to HP1112. Contains PS00163 Fumarate lyases signature and Pfam match to entry PF00206 lyase_1, Lyases, score 199.60, E-value 4.7e-56; Updated (2006) note: Characterised within Bacillus subtilis with acceptable identity scores. Thus, putative not added to product function. Functional classification -Purine ribonucleo [...] | 0.447 |
gmk | purH | Cj1177c | Cj0953c | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Original (2000) note: Cj0953c, purH,phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase, len: 510 aa; highly similar to many e.g. PUR9_ECOLI phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) / IMP cyclohydrolase (EC 3.5.4.10) (529 aa), fasta scores; opt: 812 z-score: 935.5 E(): 0, 44.6% identity in 529 aa overlap. No Hp match; Updated (2006) note: Pfam domains PF01808 AICARFT/IMPCHase bienzyme and PF02142 MGS-like domain were identified within CDS. Further support given to product function. Characterised in Escherichia coli with acceptabl [...] | 0.526 |
gmk | purN | Cj1177c | Cj0187c | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.523 |