node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CT0211 | kpsU | CT0211 | CT1830 | Acyltransferase, HtrB/MsbB family; Identified by similarity to SP:P76522; match to protein family HMM PF03279. | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.670 |
CT0211 | lpxA | CT0211 | CT2008 | Acyltransferase, HtrB/MsbB family; Identified by similarity to SP:P76522; match to protein family HMM PF03279. | acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.835 |
CT0211 | lpxB | CT0211 | CT0280 | Acyltransferase, HtrB/MsbB family; Identified by similarity to SP:P76522; match to protein family HMM PF03279. | lipid-A-disaccharide synthase, putative; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.833 |
CT0211 | lpxC/fabZ | CT0211 | CT1662 | Acyltransferase, HtrB/MsbB family; Identified by similarity to SP:P76522; match to protein family HMM PF03279. | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; In the C-terminal section; belongs to the thioester dehydratase family. | 0.721 |
CT0211 | lpxD | CT0211 | CT1360 | Acyltransferase, HtrB/MsbB family; Identified by similarity to SP:P76522; match to protein family HMM PF03279. | UDP-3-O-3-hydroxymyristoyl glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.776 |
CT0211 | lpxK | CT0211 | CT1676 | Acyltransferase, HtrB/MsbB family; Identified by similarity to SP:P76522; match to protein family HMM PF03279. | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.824 |
CT0227 | CT0251 | CT0227 | CT0251 | Identified by match to protein family HMM PF00984; match to protein family HMM PF03446; match to protein family HMM PF03720; match to protein family HMM PF03721; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. | UDP-N-acetylglucosamine pyrophosphorylase, putative; Identified by similarity to EGAD:8169; match to protein family HMM PF00483. | 0.927 |
CT0227 | lpxA | CT0227 | CT2008 | Identified by match to protein family HMM PF00984; match to protein family HMM PF03446; match to protein family HMM PF03720; match to protein family HMM PF03721; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. | acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.824 |
CT0227 | murA | CT0227 | CT0555 | Identified by match to protein family HMM PF00984; match to protein family HMM PF03446; match to protein family HMM PF03720; match to protein family HMM PF03721; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.903 |
CT0251 | CT0227 | CT0251 | CT0227 | UDP-N-acetylglucosamine pyrophosphorylase, putative; Identified by similarity to EGAD:8169; match to protein family HMM PF00483. | Identified by match to protein family HMM PF00984; match to protein family HMM PF03446; match to protein family HMM PF03720; match to protein family HMM PF03721; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. | 0.927 |
CT0251 | lpxA | CT0251 | CT2008 | UDP-N-acetylglucosamine pyrophosphorylase, putative; Identified by similarity to EGAD:8169; match to protein family HMM PF00483. | acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.846 |
CT0251 | murA | CT0251 | CT0555 | UDP-N-acetylglucosamine pyrophosphorylase, putative; Identified by similarity to EGAD:8169; match to protein family HMM PF00483. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.949 |
kpsU | CT0211 | CT1830 | CT0211 | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | Acyltransferase, HtrB/MsbB family; Identified by similarity to SP:P76522; match to protein family HMM PF03279. | 0.670 |
kpsU | lpxA | CT1830 | CT2008 | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.834 |
kpsU | lpxB | CT1830 | CT0280 | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | lipid-A-disaccharide synthase, putative; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.836 |
kpsU | lpxC/fabZ | CT1830 | CT1662 | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; In the C-terminal section; belongs to the thioester dehydratase family. | 0.533 |
kpsU | lpxD | CT1830 | CT1360 | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | UDP-3-O-3-hydroxymyristoyl glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.778 |
kpsU | lpxK | CT1830 | CT1676 | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.856 |
lpxA | CT0211 | CT2008 | CT0211 | acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | Acyltransferase, HtrB/MsbB family; Identified by similarity to SP:P76522; match to protein family HMM PF03279. | 0.835 |
lpxA | CT0227 | CT2008 | CT0227 | acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | Identified by match to protein family HMM PF00984; match to protein family HMM PF03446; match to protein family HMM PF03720; match to protein family HMM PF03721; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. | 0.824 |