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pdxH pdxH pdxT pdxT pdxS pdxS Noca_4006 Noca_4006 Noca_4436 Noca_4436 Noca_0733 Noca_0733 ribH ribH gcvP gcvP Noca_0736 Noca_0736 Noca_0737 Noca_0737 Noca_0735 Noca_0735
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
Score
pdxHPyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (213 aa)    
Predicted Functional Partners:
pdxT
Pyridoxal phosphate synthase yaaE subunit; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
    
 0.965
pdxS
Pyridoxal phosphate synthase yaaD subunit; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family.
    
 0.950
Noca_4006
KEGG: rxy:Rxyl_0612 pyridoxal kinase; TIGRFAM: pyridoxal kinase; PFAM: Phosphomethylpyrimidine kinase type-1; Belongs to the pyridoxine kinase family.
 
  
 0.932
Noca_4436
PFAM: aldo/keto reductase; KEGG: ecj:JW1403 predicted oxidoreductase, NAD(P)-binding.
     
 0.902
Noca_0733
PFAM: Citrate synthase; KEGG: sma:SAV3859 putative citrate synthase; Belongs to the citrate synthase family.
 
  
 0.736
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
     
 0.714
gcvP
Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
 
   
 0.566
Noca_0736
PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase; KEGG: fal:FRAAL0788 putative ABC phosphate-transporting ATPase.
       0.546
Noca_0737
PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase; KEGG: rha:RHA1_ro04170 bifunctional ABC lipid A exporter.
       0.546
Noca_0735
PFAM: regulatory protein, TetR; KEGG: mmc:Mmcs_2550 transcriptional regulator, TetR family.
       0.545
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614
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