STRINGSTRING
ddh ddh lysA lysA dapF dapF dapB dapB dapD dapD Cgl2135 Cgl2135 dapA dapA dapE dapE dapC dapC murE murE lysC lysC
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
ddhMESO-DIAMINOPIMELATE DEHYDROGENASE; Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate. Probably plays a role in lysine biosynthesis. Exhibits a high substrate specificity for meso-2,6-diaminopimelate, since L,L- 2,6-diaminopimelate, D,D-2,6-diaminopimelate, L-glutamate, L-alanine, L-leucine, L-valine, L-aspartate, L-threonine, L-homoserine, L- methionine, L-lysine, L-serine, L-phenylalanine, L-tyrosine, L- tryptophan, L-ornithine, L-histidine, L- [...] (320 aa)    
Predicted Functional Partners:
lysA
DIAMINOPIMELATE DECARBOXYLASE; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.
    
 0.997
dapF
Diaminopimelate Epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. Involved in the succinylase branch of the diaminopimelate biosynthesis.
     
 0.997
dapB
DIHYDRODIPICOLINATE REDUCTASE; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
 
  
 0.986
dapD
TETRAHYDRODIPICOLINATE SUCCINYLASE; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
      
 0.974
Cgl2135
Decarboxylase.
    
 0.967
dapA
DIHYDRODIPICOLINATE SYNTHASE; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
     
 0.961
dapE
SUCCINYL-DIAMINOPIMELATE DESUCCINYLASE.
   
  
 0.950
dapC
SUCCINYLDIAMINOPIMELATE AMINOTRANSFERASE.
   
  
 0.948
murE
PROBABLE UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily.
     
 0.908
lysC
ASPARTOKINASE LYSC ALPHA and beta SUBUNITs; Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine; Belongs to the aspartokinase family.
  
  
 0.799
Your Current Organism:
Corynebacterium glutamicum
NCBI taxonomy Id: 196627
Other names: C. glutamicum ATCC 13032, Corynebacterium glutamicum ATCC 13032, Corynebacterium glutamicum str. ATCC 13032, Corynebacterium glutamicum strain ATCC 13032
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