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fumC fumC mdh mdh fumA fumA maeB maeB fumB fumB sfcA sfcA glcB glcB sdhA sdhA gltA gltA frdA frdA adk adk
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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fumCFumarase C, fumarate hydratase Class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa)    
Predicted Functional Partners:
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate.
  
 0.993
fumA
Fumarase A, fumarate hydratase Class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
 
 0.988
maeB
Putative multimodular enzyme.
  
 
 0.963
fumB
Fumarase B, fumarate hydratase Class I; Code: C; COG: COG1951.
  
 
 0.959
sfcA
NAD-linked malate dehydrogenase (malic enzyme); Code: C; COG: COG0281; Belongs to the malic enzymes family.
  
 
 0.955
glcB
Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily.
    
 0.931
sdhA
Succinate dehydrogenase, flavoprotein subunit; Code: C; COG: COG1053.
 
 0.927
gltA
Citrate synthase; Code: C; COG: COG0372; Belongs to the citrate synthase family.
   
 0.927
frdA
Fumarate reductase, anaerobic, flavoprotein subunit; Code: C; COG: COG1053.
 0.914
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
      
 0.911
Your Current Organism:
Shigella flexneri
NCBI taxonomy Id: 198214
Other names: S. flexneri 2a str. 301, Shigella flexneri 2a str. 301, Shigella flexneri serotype 2a str. 301
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