STRINGSTRING
folE folE folK folK folX folX ygcM ygcM ribA ribA folP folP ygiG ygiG moaA moaA ntpA ntpA phoA phoA ndk ndk
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query proteins and first shell of interactors
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second shell of interactors
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Predicted Interactions
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textmining
co-expression
protein homology
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folEGTP cyclohydrolase I; Code: H; COG: COG0302. (222 aa)    
Predicted Functional Partners:
folK
7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; Code: H; COG: COG0801.
  
 0.997
folX
D-erythro-7,8-dihydroneopterin triphosphate epimerase; Catalyzes the epimerization of carbon 2' of the side chain of 7,8-dihydroneopterin triphosphate (H2NTP) to form 7,8-dihydromonapterin triphosphate (H2MTP). Is required for tetrahydromonapterin biosynthesis.
 
 
 0.995
ygcM
Putative 6-pyruvoyl tetrahydrobiopterin synthase; Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde.
  
 
 0.986
ribA
GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
 
 
 
 0.966
folP
7,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
 
  
 0.946
ygiG
Putative kinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6- hydroxymethyldihydropterin, but it can also catalyze the epimerization of carbon 2' of dihydroneopterin to dihydromonapterin at appreciable velocity.
 
  
 0.930
moaA
Molybdopterin biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
    
  0.911
ntpA
Dihydroneopterin triphosphate diphosphatase; Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP.
    
  0.910
phoA
Alkaline phosphatase; Code: P; COG: COG1785.
   
 
  0.900
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
   
 0.839
Your Current Organism:
Shigella flexneri
NCBI taxonomy Id: 198214
Other names: S. flexneri 2a str. 301, Shigella flexneri 2a str. 301, Shigella flexneri serotype 2a str. 301
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