STRINGSTRING
mutM mutM yacE yacE polA polA mutY mutY mutT mutT tehB tehB rpmB rpmB rpmG rpmG ybcL ybcL ybhE ybhE SF3152 SF3152
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
mutMFormamidopyrimidine DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (269 aa)    
Predicted Functional Partners:
yacE
Putative DNA repair protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
 
  
 0.966
polA
DNA polymerase I, 3 --> 5 polymerase, 5 --> 3 and 3 --> 5 exonuclease; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.928
mutY
Adenine glycosylase; Adenine glycosylase active on G-A mispairs.
  
  
 0.849
mutT
7,8-dihydro-8-oxoguanine-triphosphatase; Code: LR; COG: COG0494; Belongs to the Nudix hydrolase family.
  
   
 0.846
tehB
Tellurite resistance protein TehB; Code: QR; COG: COG0500.
      
 0.739
rpmB
50S ribosomal subunit protein L28; Code: J; COG: COG0227; Belongs to the bacterial ribosomal protein bL28 family.
     
 0.675
rpmG
50S ribosomal subunit protein L33; Code: J; COG: COG0267; Belongs to the bacterial ribosomal protein bL33 family.
     
 0.627
ybcL
Conserved hypothetical protein; Code: R; COG: COG1881.
     
 0.606
ybhE
6-phosphogluconolactonase; Catalyzes the hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate.
      
 0.594
SF3152
Putative L-serine deaminase; Code: E; COG: COG1760.
      
 0.594
Your Current Organism:
Shigella flexneri
NCBI taxonomy Id: 198214
Other names: S. flexneri 2a str. 301, Shigella flexneri 2a str. 301, Shigella flexneri serotype 2a str. 301
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