node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aroB | aroH | c4159 | c2100 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | 0.952 |
aroB | aroL | c4159 | c0495 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | Shikimate kinase II; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. | 0.996 |
aroB | pheA | c4159 | c3120 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | P-protein; Escherichia coli K-12 ortholog: b2599; Escherichia coli O157:H7 ortholog: z3891; bifunctional; Chorismate mutase; Prephenate dehydratase. | 0.824 |
aroB | ppsA | c4159 | c2098 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. | 0.752 |
aroB | tyrA | c4159 | c3121 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | T-protein; Escherichia coli K-12 ortholog: b2600; Escherichia coli O157:H7 ortholog: z3892; bifunctional; Chorismate mutase; Prephenate dehydrogenase. | 0.941 |
aroH | aroB | c2100 | c4159 | Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.952 |
aroH | aroL | c2100 | c0495 | Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | Shikimate kinase II; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. | 0.507 |
aroH | pheA | c2100 | c3120 | Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | P-protein; Escherichia coli K-12 ortholog: b2599; Escherichia coli O157:H7 ortholog: z3891; bifunctional; Chorismate mutase; Prephenate dehydratase. | 0.681 |
aroH | ppsA | c2100 | c2098 | Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. | 0.494 |
aroH | trpR | c2100 | c5480 | Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | Trp operon repressor; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region. | 0.480 |
aroH | tyrA | c2100 | c3121 | Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | T-protein; Escherichia coli K-12 ortholog: b2600; Escherichia coli O157:H7 ortholog: z3892; bifunctional; Chorismate mutase; Prephenate dehydrogenase. | 0.662 |
aroH | ydiA | c2100 | c2099 | Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | Hypothetical protein ydiA; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. | 0.481 |
aroH | ydiE | c2100 | c2101 | Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | Hypothetical protein ydiE; Escherichia coli K-12 ortholog: b1705; Escherichia coli O157:H7 ortholog: z2734. | 0.519 |
aroL | aroB | c0495 | c4159 | Shikimate kinase II; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.996 |
aroL | aroH | c0495 | c2100 | Shikimate kinase II; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. | Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | 0.507 |
aroL | pheA | c0495 | c3120 | Shikimate kinase II; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. | P-protein; Escherichia coli K-12 ortholog: b2599; Escherichia coli O157:H7 ortholog: z3891; bifunctional; Chorismate mutase; Prephenate dehydratase. | 0.827 |
aroL | ppsA | c0495 | c2098 | Shikimate kinase II; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. | 0.681 |
aroL | tyrA | c0495 | c3121 | Shikimate kinase II; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. | T-protein; Escherichia coli K-12 ortholog: b2600; Escherichia coli O157:H7 ortholog: z3892; bifunctional; Chorismate mutase; Prephenate dehydrogenase. | 0.867 |
pheA | aroB | c3120 | c4159 | P-protein; Escherichia coli K-12 ortholog: b2599; Escherichia coli O157:H7 ortholog: z3891; bifunctional; Chorismate mutase; Prephenate dehydratase. | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.824 |
pheA | aroH | c3120 | c2100 | P-protein; Escherichia coli K-12 ortholog: b2599; Escherichia coli O157:H7 ortholog: z3891; bifunctional; Chorismate mutase; Prephenate dehydratase. | Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | 0.681 |