STRINGSTRING
cyaB cyaB vfr vfr cpdA cpdA cyaA cyaA pilG pilG pilH pilH PA0275 PA0275 fimL fimL cbpA cbpA ndk ndk pykA pykA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cyaBCyaB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (463 aa)    
Predicted Functional Partners:
vfr
Transcriptional regulator Vfr; Can bind cyclic AMP. Is a global regulator of virulence factor expression and is required for exotoxin A and protease production.
 
 0.995
cpdA
Cyclic AMP (cAMP) Phosphodiesterase, CpdA; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.
  
 
 0.993
cyaA
Adenylate cyclase; Product name confidence: Class 2 (High similarity to functionally studied protein).
  
 
 0.989
pilG
Twitching motility protein PilG; Is involved in pilus biosynthesis and twitching motility. May act as a single-domain response regulator whose function may be to receive a certain environmental signal(s) and then transduce that signal to the pilus assembly machinery via specific protein-protein interactions.
 
 
 0.988
pilH
Twitching motility protein PilH; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction).
 0.978
PA0275
Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).
 
 0.962
fimL
Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
 
   
 0.931
cbpA
cAMP-binding protein A; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.
 
 0.916
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. The 12-kDa membrane-associated form synthesizes GTP in preference to other nucleoside triphosphates. Important for alginate synthesis; Belongs to the NDK family.
  
 
 0.915
pykA
Pyruvate kinase II; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the pyruvate kinase family.
   
 0.911
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.