STRINGSTRING
fpg fpg coaE coaE polA polA uvrC uvrC nth nth exo exo mutB mutB rpmB rpmB rpmG rpmG mutT mutT lexB lexB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
fpgformamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (269 aa)    
Predicted Functional Partners:
coaE
Conserved hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
 
  
 0.975
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.949
uvrC
Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
 
 
 0.826
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
   
  
 0.801
exo
Exodeoxyribonuclease IX; Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.
  
  
 0.754
mutB
A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.
  
  
 0.639
rpmB
Similar to Escherichia coli 50S ribosomal protein L28 RpmB SW:RL28_ECOLI (P02428) (77 aa) fasta scores: E(): 1.1e-32, 92.2% id in 77 aa; Belongs to the bacterial ribosomal protein bL28 family.
  
  
 0.613
rpmG
50S ribosomal protein L33; Similar to Escherichia coli and Salmonella typhimurium 50S ribosomal protein L33 SW:RL33_ECOLI (P02436) (54 aa) fasta scores: E(): 1.7e-21, 96.3% id in 54 aa; Belongs to the bacterial ribosomal protein bL33 family.
  
    0.610
mutT
Mutator protein MutT; Similar to Escherichia coli mutator protein MutT SW:MUTT_ECOLI (P08337) (129 aa) fasta scores: E(): 1.9e-28,60.2% id in 128 aa, and to Haemophilus influenzae mutator protein MutT SW:MUTT_HAEIN (P44932) (136 aa) fasta scores: E(): 5.7e-22, 51.2% id in 125 aa; Belongs to the Nudix hydrolase family.
 
  
 0.593
lexB
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
  
 0.587
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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