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tdk tdk thyA thyA dnaS dnaS tmk tmk cdd cdd b4384 b4384 udp udp YPO2295 YPO2295 YPO0141 YPO0141 YPO2559 YPO2559 prfA prfA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
tdkThymidine kinase; Similar to Escherichia coli thymidine kinase Tdk SW:KITH_ECOLI (P23331) (205 aa) fasta scores: E(): 0, 76.4% id in 191 aa, and to Vibrio cholerae thymidine kinase VC1167 TR:Q9KST9 (EMBL:AE004197) (192 aa) fasta scores: E(): 0, 72.6% id in 190 aa. (196 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.994
dnaS
Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
   
 
 0.989
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. 5-bromo-2'deoxyuridine monophosphate is also a good phosphate acceptor; Belongs to the thymidylate kinase family.
  
 
 0.979
cdd
Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
  
 
 0.975
b4384
Similar to Escherichia coli purine nucleoside phosphorylase DeoD SW:DEOD_ECOLI (P09743) (238 aa) fasta scores: E(): 0, 91.1% id in 236 aa, and to Klebsiella pneumoniae purine nucleoside phosphorylase DeoD SW:DEOD_KLEPN (Q59482) (239 aa) fasta scores: E(): 0, 88.7% id in 238 aa.
  
 
 0.955
udp
Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family.
   
 
 0.946
YPO2295
Haloacid dehalogenase-like hydrolase family protein; Similar to Vibrio cholerae hypothetical protein VCA0608 TR:Q9KLY3 (EMBL:AE004391) (224 aa) fasta scores: E(): 0, 62.9% id in 224 aa; Similar to Vibrio cholerae hypothetical protein VCA0608 TR:Q9KLY3 (EMBL:AE004391) (224 aa) fasta scores: E(): 0, 62.9% id in 224 aa, and to Escherichia coli hypothetical protein YjjG SW:YJJG_ECOLI (P33999) (225 aa) fasta scores: E(): 0, 56.8% id in 222 aa.
 
  
  0.943
YPO0141
Similar to Escherichia coli hypothetical protein YrfG SW:YRFG_ECOLI (P45801) (222 aa) fasta scores: E(): 0,67.0% id in 221 aa.
    
  0.936
YPO2559
Conserved hypothetical protein; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates.
    
  0.933
prfA
Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
  
  
 0.887
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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