Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ilvA | luxS | YPO3896 | YPO3300 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Autoinducer-2 production protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 0.933 |
| ilvA | metC | YPO3896 | YPO0278 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Cystathionine beta-lyase; Similar to Prokaryotic and Eukaryotic cystathionine beta-lyases including Escherichia coli MetC SW:METC_ECOLI (P06721) (395 aa) fasta scores: E(): 0, 42.6% id in 390 aa and Saccharomyces cerevisiae YFR055W SW:METC_YEAST (P43623) (340 aa) fasta scores: E(): 0, 64.1% id in 340 aa. | 0.552 |
| ilvA | metC-2 | YPO3896 | YPO0681 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Similar to Escherichia coli cystathionine beta-lyase MetC SW:METC_ECOLI (P06721) (395 aa) fasta scores: E(): 0,70.3% id in 391 aa, and to Salmonella typhimurium cystathionine beta-lyase MetC SW:METC_SALTY (P18949) (395 aa) fasta scores: E(): 0, 69.6% id in 391 aa. | 0.950 |
| ilvA | metE | YPO3896 | YPO3788 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 5-methyltetrahydropteroyltriglutamate--homocyste i ne methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.948 |
| ilvA | metH | YPO3896 | YPO3722 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 5-Methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.965 |
| ilvA | metL | YPO3896 | YPO0116 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Cystathionine gamma-synthase (pseudogene); PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.900 |
| ilvA | thrA | YPO3896 | YPO0459 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Similar to Escherichia coli bifunctional aspartokinase/homoserine dehydrogenase I ThrA SW:AK1H_ECOLI (P00561) (820 aa) fasta scores: E(): 0, 82.0% id in 821 aa,and to Serratia marcescens bifunctional aspartokinase/homoserine dehydrogenase I ThrA SW:AK1H_SERMA (P27725) (819 aa) fasta scores: E(): 0, 89.9% id in 819 aa; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.898 |
| ilvA | thrB | YPO3896 | YPO0460 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.615 |
| luxS | ilvA | YPO3300 | YPO3896 | Autoinducer-2 production protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.933 |
| luxS | metC | YPO3300 | YPO0278 | Autoinducer-2 production protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | Cystathionine beta-lyase; Similar to Prokaryotic and Eukaryotic cystathionine beta-lyases including Escherichia coli MetC SW:METC_ECOLI (P06721) (395 aa) fasta scores: E(): 0, 42.6% id in 390 aa and Saccharomyces cerevisiae YFR055W SW:METC_YEAST (P43623) (340 aa) fasta scores: E(): 0, 64.1% id in 340 aa. | 0.701 |
| luxS | metC-2 | YPO3300 | YPO0681 | Autoinducer-2 production protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | Similar to Escherichia coli cystathionine beta-lyase MetC SW:METC_ECOLI (P06721) (395 aa) fasta scores: E(): 0,70.3% id in 391 aa, and to Salmonella typhimurium cystathionine beta-lyase MetC SW:METC_SALTY (P18949) (395 aa) fasta scores: E(): 0, 69.6% id in 391 aa. | 0.967 |
| luxS | metE | YPO3300 | YPO3788 | Autoinducer-2 production protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 5-methyltetrahydropteroyltriglutamate--homocyste i ne methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.981 |
| luxS | metF | YPO3300 | YPO0117 | Autoinducer-2 production protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | Similar to Erwinia carotovora 5,10-methylenetetrahydrofolate reductase MetF SW:METF_ERWCA (P71319) (298 aa) fasta scores: E(): 0, 91.8% id in 294 aa,and to Escherichia coli 5,10-methylenetetrahydrofolate reductase MetF SW:METF_ECOLI (P00394) (296 aa) fasta scores: E(): 0, 86.4% id in 294 aa; deleted EC_number 1.7.99.5. | 0.549 |
| luxS | metH | YPO3300 | YPO3722 | Autoinducer-2 production protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 5-Methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.964 |
| luxS | metK | YPO3300 | YPO0931 | Autoinducer-2 production protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.447 |
| luxS | metL | YPO3300 | YPO0116 | Autoinducer-2 production protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | Cystathionine gamma-synthase (pseudogene); PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.951 |
| luxS | thrA | YPO3300 | YPO0459 | Autoinducer-2 production protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | Similar to Escherichia coli bifunctional aspartokinase/homoserine dehydrogenase I ThrA SW:AK1H_ECOLI (P00561) (820 aa) fasta scores: E(): 0, 82.0% id in 821 aa,and to Serratia marcescens bifunctional aspartokinase/homoserine dehydrogenase I ThrA SW:AK1H_SERMA (P27725) (819 aa) fasta scores: E(): 0, 89.9% id in 819 aa; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.951 |
| metC | ilvA | YPO0278 | YPO3896 | Cystathionine beta-lyase; Similar to Prokaryotic and Eukaryotic cystathionine beta-lyases including Escherichia coli MetC SW:METC_ECOLI (P06721) (395 aa) fasta scores: E(): 0, 42.6% id in 390 aa and Saccharomyces cerevisiae YFR055W SW:METC_YEAST (P43623) (340 aa) fasta scores: E(): 0, 64.1% id in 340 aa. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.552 |
| metC | luxS | YPO0278 | YPO3300 | Cystathionine beta-lyase; Similar to Prokaryotic and Eukaryotic cystathionine beta-lyases including Escherichia coli MetC SW:METC_ECOLI (P06721) (395 aa) fasta scores: E(): 0, 42.6% id in 390 aa and Saccharomyces cerevisiae YFR055W SW:METC_YEAST (P43623) (340 aa) fasta scores: E(): 0, 64.1% id in 340 aa. | Autoinducer-2 production protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 0.701 |
| metC | metC-2 | YPO0278 | YPO0681 | Cystathionine beta-lyase; Similar to Prokaryotic and Eukaryotic cystathionine beta-lyases including Escherichia coli MetC SW:METC_ECOLI (P06721) (395 aa) fasta scores: E(): 0, 42.6% id in 390 aa and Saccharomyces cerevisiae YFR055W SW:METC_YEAST (P43623) (340 aa) fasta scores: E(): 0, 64.1% id in 340 aa. | Similar to Escherichia coli cystathionine beta-lyase MetC SW:METC_ECOLI (P06721) (395 aa) fasta scores: E(): 0,70.3% id in 391 aa, and to Salmonella typhimurium cystathionine beta-lyase MetC SW:METC_SALTY (P18949) (395 aa) fasta scores: E(): 0, 69.6% id in 391 aa. | 0.445 |
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