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metC metC metA metA metH metH metE metE cbs cbs metB metB metZ metZ MMAR_3453 MMAR_3453 sahH sahH MMAR_1183 MMAR_1183 thrA thrA
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
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experimentally determined
Predicted Interactions
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textmining
co-expression
protein homology
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metCO-acetylhomoserine sulfhydrylase MetC; Transforms O-acetylhomoserine into L-methionine [catalytic activity: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate]. (449 aa)    
Predicted Functional Partners:
metA
Homoserine O-acetyltransferase MetA; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
 
 
 0.999
metH
5-methyltetrahydrofolate--homocysteine methyltransferase, MetH; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.969
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase MetE; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 
 0.956
cbs
Cystathionine beta-synthase Cbs; Thought to be involved in homocysteine transulfuration [catalytic activity: L-serine + L- homocysteine = cystathionine + H2O].
 
 
 0.951
metB
Cystathionine gamma-synthase MetB (cgs); Involved in methionine biosynthesis: converts O- succinyl-L-homoserine to cystathionine [catalytic activity : O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate (can also use hydrogen sulfide and methanethiol as substrates)].
 
 
0.949
metZ
O-succinylhomoserine sulfhydrylase, MetZ; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide.
 
 
0.941
MMAR_3453
Aminotransferase.
   
 0.936
sahH
Adenosylhomocysteinase SahH; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
    
 0.916
MMAR_1183
Methyltransferase; Causes methylation.
  
  
 0.908
thrA
Homoserine dehydrogenase ThrA; Involved in the conversion of l-aspartate to homoserine (third step). homoserine participates in the biosynthesis of threonine and then isoleucine and in the biosynthesis of methionine [catalytic activity : L- homoserine + NAD(P)(+) = l-aspartate 4-semialdehyde + NAD(P)H.].
 
 
 0.890
Your Current Organism:
Mycobacterium marinum
NCBI taxonomy Id: 216594
Other names: M. marinum M, Mycobacterium marinum M, Mycobacterium marinum str. M, Mycobacterium marinum strain M
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