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proB proB proA proA obg obg proC proC rocD rocD rocA rocA rpmA rpmA rplU rplU argB argB gltB gltB rne rne
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
proBGlutamate 5-kinase protein ProB; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (368 aa)    
Predicted Functional Partners:
proA
Gamma-glutamyl phosphate reductase protein ProA; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.
 
 0.999
obg
GTP1/OBG-family GTP-binding protein Obg; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
  
  
 0.958
proC
Pyrroline-5-carboxylate reductase ProC; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
 
 
 0.952
rocD
Ornithine aminotransferase RocD1 and RocD2; Involved in arginine metabolism [catalytic activity: L-ornithine + a 2-OXO acid = L-glutamate 5- semialdehyde + an L-amino acid]; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
   
 0.928
rocA
Pyrroline-5-carboxylate dehydrogenase, RocA; Involved in the arginase pathway [catalytic activity: 1-pyrroline-5-carboxylate + NAD(+) + H(2)O = L- glutamate + NADH].
  
 
 0.915
rpmA
50S ribosomal protein L27 RpmA; Involved in translation mechanisms; Belongs to the bacterial ribosomal protein bL27 family.
     
 0.902
rplU
50S ribosomal protein L21 RplU; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.
     
 0.811
argB
Acetylglutamate kinase ArgB; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily.
 
 
 
 0.748
gltB
Ferredoxin-dependent glutamate synthase [NADPH] (large subunit) GltB; Probably involved in glutamate biosynthesis [catalytic activity: 2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH].
     
 0.736
rne
Ribonuclease E Rne; Thought to be involved in several cellular process.
  
    0.665
Your Current Organism:
Mycobacterium marinum
NCBI taxonomy Id: 216594
Other names: M. marinum M, Mycobacterium marinum M, Mycobacterium marinum str. M, Mycobacterium marinum strain M
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