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hemL hemL hemB_1 hemB_1 hemB_2 hemB_2 hemA hemA PFL_3222 PFL_3222 hemC hemC thiE thiE cobA cobA thiD thiD pvdJ pvdJ pchE pchE
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
Score
hemLGlutamate-1-semialdehyde-2,1-aminomutase; Identified by similarity to SP:P48247; match to protein family HMM PF00202; match to protein family HMM TIGR00713. (427 aa)    
Predicted Functional Partners:
hemB_1
Porphobilinogen synthase; Identified by match to protein family HMM PF00490; Belongs to the ALAD family.
 
 
 0.987
hemB_2
Porphobilinogen synthase; Identified by similarity to SP:Q59643; match to protein family HMM PF00490; Belongs to the ALAD family.
 
 
 0.987
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.986
PFL_3222
Aminotransferase, class III; Identified by match to protein family HMM PF00202; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
  
 
0.919
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
  
 0.904
thiE
Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
    
 0.875
cobA
Siroheme synthase/uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
   
 0.755
thiD
Putative phosphomethylpyrimidine kinase; Identified by match to protein family HMM PF08543.
  
  
 0.738
pvdJ
Non-ribosomal peptide synthetase PvdJ; Identified by match to protein family HMM PF00501; match to protein family HMM PF00550; match to protein family HMM PF00668; match to protein family HMM TIGR01733.
  
 
 0.710
pchE
Enantio-pyochelin synthetase E; Previously identified and characterized. See Youard et al 2007 (PMID: 17938167) for more information; identified by similarity to GB:ABW70809.1; match to protein family HMM PF00501; match to protein family HMM PF00550; match to protein family HMM PF00668; match to protein family HMM PF08415; match to protein family HMM TIGR01733.
  
 
 0.709
Your Current Organism:
Pseudomonas protegens
NCBI taxonomy Id: 220664
Other names: P. protegens Pf-5, Pseudomonas fluorescens Pf-5, Pseudomonas protegens Pf-5, Pseudomonas protegens str. Pf-5, Pseudomonas protegens strain Pf-5, Pseudomonas sp. Pf-5
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