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phhB phhB phhA phhA hppD hppD hmgA hmgA fahA fahA phhR phhR aspC aspC tyrB tyrB maiA maiA pheA pheA purL purL
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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phhBPterin-4-alpha-carbinolamine dehydratase; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. May also have a positive regulatory role in the expression of phhA (By similarity); Belongs to the pterin-4-alpha-carbinolamine dehydratase family. (118 aa)    
Predicted Functional Partners:
phhA
Phenylalanine-4-hydroxylase; Identified by match to TIGR protein family HMM TIGR01270.
 
 0.995
hppD
4-hydroxyphenylpyruvate dioxygenase; Identified by match to PFAM protein family HMM PF00903; see PMID:20190049 for expression data; identified by match to PFAM protein family HMM PF00903.
  
  
 0.706
hmgA
Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.
  
  
 0.659
fahA
Fumarylacetoacetase; See PMID:20190049 for expression data.
  
  
 0.504
phhR
Phenylalanine hydroxylase transcriptional activator PhhR.
     
 0.462
aspC
Aspartate aminotransferase; See PMID:20190049 for expression data.
  
  
 0.462
tyrB
Aromatic-amino-acid aminotransferase; See PMID:20190049 for expression data; similar to GP:13364513, and SP:P04693; identified by sequence similarity; putative.
  
  
 0.462
maiA
Maleylacetoacetate isomerase; See PMID:20190049 for expression data; identified by match to PFAM protein family HMM PF02798.
  
  
 0.442
pheA
Chorismate mutase/prephenate dehydratase; See PMID:20190049 for expression data.
      
 0.426
purL
Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
      
 0.424
Your Current Organism:
Pseudomonas syringae tomato
NCBI taxonomy Id: 223283
Other names: P. syringae pv. tomato str. DC3000, Pseudomonas syringae DC3000, Pseudomonas syringae pv. tomato DC3000, Pseudomonas syringae pv. tomato str. ATCC BAA-871, Pseudomonas syringae pv. tomato str. DC3000
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