STRINGSTRING
tagD tagD tagF tagF tagB tagB gpsA gpsA tagA tagA tagG tagG tagE tagE tagH tagH tagO tagO glpD glpD plsY plsY
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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tagDGlycerol-3-phosphate cytidylyltransferase; Catalyzes the transfer of the cytidylyl group of CTP to sn- glycerol 3-phosphate so the activated glycerol 3-phosphate can be used for teichoic acid synthesis, via incorporation into both the linkage unit and the teichoic acid polymer by TagB and TagF. Belongs to the cytidylyltransferase family. (129 aa)    
Predicted Functional Partners:
tagF
Teichoic acid poly(glycerol phosphate) polymerase; Responsible for the polymerization of the main chain of the major teichoic acid by sequential transfer of glycerol phosphate units from CDP-glycerol to the disaccharide linkage unit. Synthesizes polymers of approximately 35 glycerol phosphate units in length.
 
  
 0.992
tagB
Teichoic acid glycerol-phosphate primase; Catalyzes the addition of a single glycerol phosphate residue to the prenoldiphosphate-linked disaccharide, as a primer for polymerisation by TagF; Belongs to the CDP-glycerol glycerophosphotransferase family.
 
  
 0.990
gpsA
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Involved in the biosynthesis of the sn-glycerol 3-phosphate required for phospholipid synthesis.
   
 0.989
tagA
N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase; Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid. Belongs to the glycosyltransferase 26 family. TagA/TarA subfamily.
 
  
 0.970
tagG
Teichoic acid precursors permease; Part of the ABC transporter complex TagGH (TC 3.A.1.34.1) involved in exporting the two types of intracellularly synthesized teichoic acids. Probably responsible for the translocation of the substrate across the membrane; Belongs to the ABC-2 integral membrane protein family.
 
  
 0.963
tagE
UDP-glucose:polyglycerol phosphate alpha-glucosyltransferase; Catalyzes the addition of glucose to the C-2 hydroxy group of the glycerol units in teichoic acid.
  
  
 0.949
tagH
Teichoic acids export ATP-binding protein TagH; Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system.
 
  
 0.946
tagO
UDP-N-acetylglucosamine:undecaprenyl-P N-acetylglucosaminyl-1-P transferase; Catalyzes the formation of undecaprenyl-PP-N- acetylglucosamine. Involved in the synthesis of anionic cell-wall polymers as it mediates the initiation of the linkage unit formation that appears to be common to the two types of teichoic acids attached to the peptidoglycan of B.subtilis; may also be involved in teichuronic acid biosynthesis (Probable); Belongs to the glycosyltransferase 4 family.
 
  
 0.914
glpD
Glycerol-3-phosphate oxidase; Evidence 2a: Function of homologous gene experimentally demonstrated in an other organism; Product type e: enzyme.
     
 0.904
plsY
Acylphosphate:glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP; Belongs to the PlsY family.
   
 
  0.901
Your Current Organism:
Bacillus subtilis 168
NCBI taxonomy Id: 224308
Other names: B. subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis 168, Bacillus subtilis subsp. subtilis str. 168, Bacillus subtilis subsp. subtilis str. BGSC 1A700
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