node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cheR | walK | BSU22720 | BSU40400 | Methyl-accepting chemotaxis proteins (MCPs) methyltransferase; Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP. CheR is responsible for the chemotactic adaptation to repellents. | Two-component sensor histidine kinase [YycG]; Member of the two-component regulatory system WalK/WalR involved in the regulation of the ftsAZ operon, the yocH and ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Phosphorylates WalR. | 0.843 |
htrC | walH | BSU40360 | BSU40390 | Putative sensor protein; Evidence 7: Gene remnant; Product type pr: putative regulator. | Regulator of YycFG; Together with YycI, regulates the activity of the two- component system WalR/WalK. | 0.917 |
htrC | walJ | BSU40360 | BSU40370 | Putative sensor protein; Evidence 7: Gene remnant; Product type pr: putative regulator. | Putative hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the metallo-beta-lactamase superfamily. | 0.954 |
htrC | walK | BSU40360 | BSU40400 | Putative sensor protein; Evidence 7: Gene remnant; Product type pr: putative regulator. | Two-component sensor histidine kinase [YycG]; Member of the two-component regulatory system WalK/WalR involved in the regulation of the ftsAZ operon, the yocH and ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Phosphorylates WalR. | 0.874 |
htrC | walR | BSU40360 | BSU40410 | Putative sensor protein; Evidence 7: Gene remnant; Product type pr: putative regulator. | Two-component response regulator [YycF]; Member of the two-component regulatory system WalK/WalR involved in the regulation of the ftsAZ operon, the yocH, ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Binds to the ftsAZ P1 promoter sequence in vitro. WalR has been shown to directly bind to the regulatory regions of yocH, ykvT, tagAB/tagDEF. Activates cwlO, lytE and ydjM and represses yoeB and yjeA. | 0.891 |
htrC | yycI | BSU40360 | BSU40380 | Putative sensor protein; Evidence 7: Gene remnant; Product type pr: putative regulator. | Regulator of YycFG; Together with YycH, regulates the activity of the two- component system WalR/WalK. | 0.909 |
mprF | walH | BSU08425 | BSU40390 | Phosphatidylglycerol lysyltransferase involved in lysinylation of phospholipids; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects B.subtilis against its own CAMPs and against those produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with po [...] | Regulator of YycFG; Together with YycI, regulates the activity of the two- component system WalR/WalK. | 0.526 |
mprF | walK | BSU08425 | BSU40400 | Phosphatidylglycerol lysyltransferase involved in lysinylation of phospholipids; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects B.subtilis against its own CAMPs and against those produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with po [...] | Two-component sensor histidine kinase [YycG]; Member of the two-component regulatory system WalK/WalR involved in the regulation of the ftsAZ operon, the yocH and ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Phosphorylates WalR. | 0.829 |
mprF | walR | BSU08425 | BSU40410 | Phosphatidylglycerol lysyltransferase involved in lysinylation of phospholipids; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects B.subtilis against its own CAMPs and against those produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with po [...] | Two-component response regulator [YycF]; Member of the two-component regulatory system WalK/WalR involved in the regulation of the ftsAZ operon, the yocH, ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Binds to the ftsAZ P1 promoter sequence in vitro. WalR has been shown to directly bind to the regulatory regions of yocH, ykvT, tagAB/tagDEF. Activates cwlO, lytE and ydjM and represses yoeB and yjeA. | 0.555 |
mprF | yycI | BSU08425 | BSU40380 | Phosphatidylglycerol lysyltransferase involved in lysinylation of phospholipids; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects B.subtilis against its own CAMPs and against those produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with po [...] | Regulator of YycFG; Together with YycH, regulates the activity of the two- component system WalR/WalK. | 0.431 |
phoP | walK | BSU29110 | BSU40400 | Two-component response regulator; Member of the two-component regulatory system PhoP/PhoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase. | Two-component sensor histidine kinase [YycG]; Member of the two-component regulatory system WalK/WalR involved in the regulation of the ftsAZ operon, the yocH and ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Phosphorylates WalR. | 0.922 |
resD | walK | BSU23120 | BSU40400 | Two-component response regulator; Member of the two-component regulatory system ResD/ResE. Required for the expression of resA, ctaA, qcrABC and fnr; activation role in global regulation of aerobic and anaerobic respiration. | Two-component sensor histidine kinase [YycG]; Member of the two-component regulatory system WalK/WalR involved in the regulation of the ftsAZ operon, the yocH and ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Phosphorylates WalR. | 0.855 |
walH | htrC | BSU40390 | BSU40360 | Regulator of YycFG; Together with YycI, regulates the activity of the two- component system WalR/WalK. | Putative sensor protein; Evidence 7: Gene remnant; Product type pr: putative regulator. | 0.917 |
walH | mprF | BSU40390 | BSU08425 | Regulator of YycFG; Together with YycI, regulates the activity of the two- component system WalR/WalK. | Phosphatidylglycerol lysyltransferase involved in lysinylation of phospholipids; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects B.subtilis against its own CAMPs and against those produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with po [...] | 0.526 |
walH | walJ | BSU40390 | BSU40370 | Regulator of YycFG; Together with YycI, regulates the activity of the two- component system WalR/WalK. | Putative hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the metallo-beta-lactamase superfamily. | 0.992 |
walH | walK | BSU40390 | BSU40400 | Regulator of YycFG; Together with YycI, regulates the activity of the two- component system WalR/WalK. | Two-component sensor histidine kinase [YycG]; Member of the two-component regulatory system WalK/WalR involved in the regulation of the ftsAZ operon, the yocH and ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Phosphorylates WalR. | 0.999 |
walH | walR | BSU40390 | BSU40410 | Regulator of YycFG; Together with YycI, regulates the activity of the two- component system WalR/WalK. | Two-component response regulator [YycF]; Member of the two-component regulatory system WalK/WalR involved in the regulation of the ftsAZ operon, the yocH, ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Binds to the ftsAZ P1 promoter sequence in vitro. WalR has been shown to directly bind to the regulatory regions of yocH, ykvT, tagAB/tagDEF. Activates cwlO, lytE and ydjM and represses yoeB and yjeA. | 0.992 |
walH | yycI | BSU40390 | BSU40380 | Regulator of YycFG; Together with YycI, regulates the activity of the two- component system WalR/WalK. | Regulator of YycFG; Together with YycH, regulates the activity of the two- component system WalR/WalK. | 0.999 |
walJ | htrC | BSU40370 | BSU40360 | Putative hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the metallo-beta-lactamase superfamily. | Putative sensor protein; Evidence 7: Gene remnant; Product type pr: putative regulator. | 0.954 |
walJ | walH | BSU40370 | BSU40390 | Putative hydrolase; Evidence 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe: putative enzyme; Belongs to the metallo-beta-lactamase superfamily. | Regulator of YycFG; Together with YycI, regulates the activity of the two- component system WalR/WalK. | 0.992 |