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icd icd acnA acnA sucA sucA CBU_1204 CBU_1204 aspB aspB mdh mdh nadB nadB sucC sucC purB purB CBU_0641 CBU_0641 CBU_1226 CBU_1226
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
icdIsocitrate dehydrogenase (NADP); Belongs to the isocitrate and isopropylmalate dehydrogenases family. (428 aa)    
Predicted Functional Partners:
acnA
Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
 0.986
sucA
2-oxoglutarate dehydrogenase E1 component; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
   
 
 0.972
CBU_1204
Succinate-semialdehyde dehydrogenase (NADP+); Belongs to the aldehyde dehydrogenase family.
 
 0.882
aspB
Succinyldiaminopimelate aminotransferase.
   
 0.870
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
  
 
 0.868
nadB
L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate.
     
 0.836
sucC
succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
  
 0.825
purB
Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
    
  0.820
CBU_0641
Leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 0.812
CBU_1226
NAD-specific glutamate dehydrogenase.
     
  0.800
Your Current Organism:
Coxiella burnetii
NCBI taxonomy Id: 227377
Other names: C. burnetii RSA 493, Coxiella burnetii RSA 493, Coxiella burnetii str. RSA 493
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