STRINGSTRING
fumC fumC sdhA sdhA maeB maeB mdh mdh sdhB sdhB sdhC sdhC aceB aceB sdhD sdhD gltA gltA HNE_3453 HNE_3453 HNE_3454 HNE_3454
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (466 aa)    
Predicted Functional Partners:
sdhA
Succinate dehydrogenase, flavoprotein subunit; Identified by similarity to SP:P31038; match to protein family HMM PF00890; match to protein family HMM PF01266; match to protein family HMM PF02910; match to protein family HMM PF07992; match to protein family HMM TIGR01812; match to protein family HMM TIGR01816; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
 
 0.996
maeB
NADP-dependent malic enzyme; Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.
  
 
 0.979
mdh
Malate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 0.972
sdhB
Succinate dehydrogenase, iron-sulfur protein; Identified by match to protein family HMM TIGR00384; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
  
 0.971
sdhC
Succinate dehydrogenase, cytochrome b556 subunit; Identified by match to protein family HMM PF01127; match to protein family HMM TIGR02970.
  
 
 0.966
aceB
Malate synthase A; Identified by match to protein family HMM PF01274; match to protein family HMM TIGR01344.
    
 0.937
sdhD
Succinate dehydrogenase, hydrophobic membrane anchor protein; Identified by match to protein family HMM PF01127; match to protein family HMM TIGR02968.
  
 
 0.919
gltA
Citrate synthase I; Identified by similarity to SP:P51037; match to protein family HMM PF00285; match to protein family HMM TIGR01798; Belongs to the citrate synthase family.
  
 0.888
HNE_3453
Identified by match to protein family HMM PF00285; Belongs to the citrate synthase family.
  
 0.888
HNE_3454
Identified by match to protein family HMM PF00285.
  
 0.888
Your Current Organism:
Hyphomonas neptunium
NCBI taxonomy Id: 228405
Other names: H. neptunium ATCC 15444, Hyphomonas neptunium ATCC 15444, Hyphomonas neptunium str. ATCC 15444, Hyphomonas neptunium strain ATCC 15444
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.