node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACP_0181 | ACP_2406 | ACP_0181 | ACP_2406 | Sensor histidine kinase; Identified by match to protein family HMM PF00512; match to protein family HMM PF00989; match to protein family HMM PF01590; match to protein family HMM PF02518; match to protein family HMM PF08448; match to protein family HMM TIGR00229. | Heat shock protein, Hsp20 family; Identified by match to protein family HMM PF00011; Belongs to the small heat shock protein (HSP20) family. | 0.540 |
ACP_0181 | clpC | ACP_0181 | ACP_2765 | Sensor histidine kinase; Identified by match to protein family HMM PF00512; match to protein family HMM PF00989; match to protein family HMM PF01590; match to protein family HMM PF02518; match to protein family HMM PF08448; match to protein family HMM TIGR00229. | ATP-dependent Clp protease, ATP-binding subunit ClpC; Identified by similarity to SP:P37571; similarity to GB:AAC44446.1; match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | 0.435 |
ACP_0181 | dnaK | ACP_0181 | ACP_0797 | Sensor histidine kinase; Identified by match to protein family HMM PF00512; match to protein family HMM PF00989; match to protein family HMM PF01590; match to protein family HMM PF02518; match to protein family HMM PF08448; match to protein family HMM TIGR00229. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.589 |
ACP_0181 | grpE | ACP_0181 | ACP_2087 | Sensor histidine kinase; Identified by match to protein family HMM PF00512; match to protein family HMM PF00989; match to protein family HMM PF01590; match to protein family HMM PF02518; match to protein family HMM PF08448; match to protein family HMM TIGR00229. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.481 |
ACP_0181 | hscA | ACP_0181 | ACP_2549 | Sensor histidine kinase; Identified by match to protein family HMM PF00512; match to protein family HMM PF00989; match to protein family HMM PF01590; match to protein family HMM PF02518; match to protein family HMM PF08448; match to protein family HMM TIGR00229. | Fe-S protein assembly chaperone HscA; Identified by match to protein family HMM PF00012; match to protein family HMM TIGR01991; Belongs to the heat shock protein 70 family. | 0.589 |
ACP_2406 | ACP_0181 | ACP_2406 | ACP_0181 | Heat shock protein, Hsp20 family; Identified by match to protein family HMM PF00011; Belongs to the small heat shock protein (HSP20) family. | Sensor histidine kinase; Identified by match to protein family HMM PF00512; match to protein family HMM PF00989; match to protein family HMM PF01590; match to protein family HMM PF02518; match to protein family HMM PF08448; match to protein family HMM TIGR00229. | 0.540 |
ACP_2406 | clpB | ACP_2406 | ACP_2407 | Heat shock protein, Hsp20 family; Identified by match to protein family HMM PF00011; Belongs to the small heat shock protein (HSP20) family. | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.896 |
ACP_2406 | clpC | ACP_2406 | ACP_2765 | Heat shock protein, Hsp20 family; Identified by match to protein family HMM PF00011; Belongs to the small heat shock protein (HSP20) family. | ATP-dependent Clp protease, ATP-binding subunit ClpC; Identified by similarity to SP:P37571; similarity to GB:AAC44446.1; match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | 0.813 |
ACP_2406 | dnaK | ACP_2406 | ACP_0797 | Heat shock protein, Hsp20 family; Identified by match to protein family HMM PF00011; Belongs to the small heat shock protein (HSP20) family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.490 |
ACP_2406 | grpE | ACP_2406 | ACP_2087 | Heat shock protein, Hsp20 family; Identified by match to protein family HMM PF00011; Belongs to the small heat shock protein (HSP20) family. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.563 |
ACP_2406 | hscA | ACP_2406 | ACP_2549 | Heat shock protein, Hsp20 family; Identified by match to protein family HMM PF00011; Belongs to the small heat shock protein (HSP20) family. | Fe-S protein assembly chaperone HscA; Identified by match to protein family HMM PF00012; match to protein family HMM TIGR01991; Belongs to the heat shock protein 70 family. | 0.490 |
ACP_2406 | hslU | ACP_2406 | ACP_2657 | Heat shock protein, Hsp20 family; Identified by match to protein family HMM PF00011; Belongs to the small heat shock protein (HSP20) family. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.441 |
ACP_2406 | hslV | ACP_2406 | ACP_2656 | Heat shock protein, Hsp20 family; Identified by match to protein family HMM PF00011; Belongs to the small heat shock protein (HSP20) family. | ATP-dependent protease HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.456 |
ACP_2406 | nnrD | ACP_2406 | ACP_3159 | Heat shock protein, Hsp20 family; Identified by match to protein family HMM PF00011; Belongs to the small heat shock protein (HSP20) family. | YjeF family protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...] | 0.428 |
clpB | ACP_2406 | ACP_2407 | ACP_2406 | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Heat shock protein, Hsp20 family; Identified by match to protein family HMM PF00011; Belongs to the small heat shock protein (HSP20) family. | 0.896 |
clpB | dnaK | ACP_2407 | ACP_0797 | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.959 |
clpB | grpE | ACP_2407 | ACP_2087 | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.858 |
clpB | hscA | ACP_2407 | ACP_2549 | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Fe-S protein assembly chaperone HscA; Identified by match to protein family HMM PF00012; match to protein family HMM TIGR01991; Belongs to the heat shock protein 70 family. | 0.959 |
clpB | hslU | ACP_2407 | ACP_2657 | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.569 |
clpB | hslV | ACP_2407 | ACP_2656 | ATP-dependent chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent protease HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.442 |