STRINGSTRING
ACP_3506 ACP_3506 ku ku polA polA dnaN dnaN ACP_1624 ACP_1624 dndD dndD ACP_2652 ACP_2652 ACP_0995 ACP_0995 ACP_1651 ACP_1651 rpoA rpoA ACP_3189 ACP_3189
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACP_3506Putative DNA ligase, ATP-dependent; Identified by match to protein family HMM PF01068; match to protein family HMM PF01896; match to protein family HMM PF04679; match to protein family HMM TIGR02776; match to protein family HMM TIGR02777; match to protein family HMM TIGR02778; match to protein family HMM TIGR02779. (863 aa)    
Predicted Functional Partners:
ku
Ku protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.973
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.961
dnaN
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.952
ACP_1624
PHP domain protein; Identified by match to protein family HMM PF00633; match to protein family HMM PF02811.
  
 0.841
dndD
DNA sulfur modification protein DndD; Identified by similarity to GB:BAC70641.1; match to protein family HMM TIGR03185.
   
 0.779
ACP_2652
DNA ligase, ATP-dependent; Identified by similarity to SP:Q9HHC4; match to protein family HMM PF01068; match to protein family HMM PF04675; match to protein family HMM PF04679; match to protein family HMM TIGR00574.
 
   
 0.719
ACP_0995
Conserved hypothetical protein; Identified by similarity to GB:CAC41728.1; match to protein family HMM PF05974.
 
     0.707
ACP_1651
Putative DnaQ family exonuclease/DinG family helicase.
   
 
 0.672
rpoA
DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
     
 0.662
ACP_3189
Putative helicase, ATP-dependent; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF04851.
   
 
 0.642
Your Current Organism:
Acidobacterium capsulatum
NCBI taxonomy Id: 240015
Other names: A. capsulatum ATCC 51196, Acidobacterium capsulatum ATCC 51196, Acidobacterium capsulatum str. ATCC 51196, Acidobacterium capsulatum strain ATCC 51196
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.