STRINGSTRING
hisD hisD hisBD hisBD hisC hisC hisG hisG hisF hisF hisH hisH hisI hisI hisA hisA hisI-2 hisI-2 RB1412 RB1412 argJ argJ
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (460 aa)    
Predicted Functional Partners:
hisBD
Best DB hits: BLAST: ddbj:BAB07300.1; (AP001519) imidazoleglycerol-phosphate; E=3e-49 swissprot:O33564; HIS7_RHOSH IMIDAZOLEGLYCEROL-PHOSPHATE; E=1e-48 swissprot:P34047; HIS7_ARATH IMIDAZOLEGLYCEROL-PHOSPHATE; E=2e-48 COG: BH3581; COG0131 Imidazoleglycerol-phosphate dehydratase; E=3e-50 PFAM: PF00475; Imidazoleglycerol-phosphate dehydrat; E=7e-96.
  
 0.998
hisC
Histidinol-phosphate aminotransferase; PMID: 1400209 best DB hits: BLAST: swissprot:P73807; HIS8_SYNY3 HISTIDINOL-PHOSPHATE AMINOTRANSFERASE; E=1e-56 swissprot:P45358; HIS8_ACEXY HISTIDINOL-PHOSPHATE AMINOTRANSFERASE; E=2e-52 gb:AAK00147.1; AF222753_2 (AF222753) putative aminotransferase; E=2e-43 COG: sll1958; COG0079 Histidinol-phosphate aminotransferase/Tyrosine; E=1e-57 PFAM: PF00155; Aminotransferase class-I; E=5.1e-06 PF00222; Aminotransferase class-II; E=1.3e-17; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase s [...]
  
 0.997
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
  
 0.995
hisF
Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
 0.993
hisH
Amidotransferase hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
  
 0.992
hisI
phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
 
  
 0.981
hisA
PMID: 2664449 best DB hits: BLAST: swissprot:P74561; HIS4_SYNY3; E=3e-56 pir:A83003; phosphoribosylformimino-5-aminoimidazole carboxamide; E=5e-49 gb:AAF05093.1; AF150930_2 (AF150930) phosphoribosyl; E=2e-46 COG: slr0652; COG0106 Phosphoribosylformimino-5-aminoimidazole; E=3e-57 PA5141; COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide; E=5e-50 NMB0629; COG0106 Phosphoribosylformimino-5-aminoimidazole; E=6e-44 PFAM: PF00977; Histidine biosynthesis protein; E=4.7e-70.
 
  
 0.981
hisI-2
Probable phosphoribosyl-ATP pyrophosphatase; PMID: 3062174 best DB hits: BLAST: swissprot:O30723; HIS2_RHOCA PHOSPHORIBOSYL-ATP PYROPHOSPHATASE; E=2e-10 swissprot:P26722; HIS2_AZOBR PHOSPHORIBOSYL-ATP PYROPHOSPHATASE; E=6e-08 pir:D81178; phosphoribosyl-ATP cyclohydrolase NMB0603 [imported] -; E=8e-08 COG: NMB0603; COG0140 Phosphoribosyl-ATP pyrophosphohydrolase; E=8e-09 PFAM: PF01503; Phosphoribosyl-ATP pyrophosphohydrol; E=9.2e-30.
 
  
 0.964
RB1412
Inositol monophosphatase family protein; PMID: 8626508 best DB hits: BLAST: swissprot:P56160; YHEB_CHLVI HYPOTHETICAL 28.2 KD PROTEIN IN HEMB; E=5e-37 pir:B70646; probable monophosphatase - Mycobacterium tuberculosis; E=4e-34 embl:CAB94593.1; (AL359214) putative monophosphatase; E=2e-33 COG: Rv3137; COG0483 Archaeal fructose-1,6-bisphosphatase and related; E=4e-35 VC2722; COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS); E=2e-13 VC0745; COG0483 Archaeal fructose-1,6-bisphosphatase and related; E=3e-12 PFAM: PF00459; Inositol monophosphatase family; E=6.9e-53.
  
 
 0.918
argJ
Arginine biosynthesis bifunctional protein argJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family.
 
  
 0.717
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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