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pknB-11 pknB-11 cnrH cnrH Pph1 Pph1 RB3245 RB3245 RB9849 RB9849 RB9844 RB9844 hemA hemA thyA thyA RB6417 RB6417 comE comE RB1789 RB1789
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pknB-11Best DB hits: BLAST: pir:T36717; probable serinethreonine protein kinase - Streptomyces; E=4e-44 swissprot:P54744; PKNB_MYCLE PUTATIVE SERINETHREONINE-PROTEIN; E=5e-44 swissprot:P71584; PKNB_MYCTU PUTATIVE SERINETHREONINE-PROTEIN; E=3e-43 COG: Rv0014c_1; COG0515 Serine/threonine protein kinases; E=3e-44 PFAM: PF00069; Protein kinase domain; E=2.2e-48. (564 aa)    
Predicted Functional Partners:
cnrH
PMID: 8052622 best DB hits: BLAST: swissprot:P37978; CNRH_ALCEU RNA POLYMERASE SIGMA FACTOR CNRH; E=5e-04 pir:G83282; probable sigma-70 factor, ECF subfamily PA2896; E=0.008 pir:S74832; transcription initiation factor sigma E sll0856 -; E=0.055 COG: PA2896; COG1595 DNA-directed RNA polymerase specialized sigma; E=8e-04 PFAM: PF00776; Sigma-70 factor (ECF subfamily); E=0.028 PF00140; Sigma-70 factor; E=0.028.
   
   0.814
Pph1
Probable protein phosphatase 1; PMID: 11298281 best DB hits: BLAST: gb:AAF81068.1; AF223364_3 (AF223364) protein phosphatase 1; E=9e-32 pir:E71538; hypothetical protein CT259 - Chlamydia trachomatis; E=4e-28 pir:H75265; conserved hypothetical protein - Deinococcus radiodurans; E=5e-28 COG: CT259; COG0631 Protein serine/threonine phosphatases; E=4e-29 PFAM: PF00481; Protein phosphatase 2C; E=4.9e-09.
 
   0.799
RB3245
Protein phosphatase 1; PMID: 11298281 best DB hits: BLAST: gb:AAF81068.1; AF223364_3 (AF223364) protein phosphatase 1; E=3e-27 pir:E71538; hypothetical protein CT259 - Chlamydia trachomatis; E=5e-26 embl:CAA10712.1; (AJ132604) pppL protein [Lactococcus lactis]; E=2e-25 COG: CT259; COG0631 Protein serine/threonine phosphatases; E=4e-27 PFAM: PF00481; Protein phosphatase 2C; E=1.2e-09.
  
   0.797
RB9849
Best DB hits: BLAST: pir:T34929; hypothetical protein SC3F9.07 SC3F9.07 - Streptomyces; E=3e-04.
       0.617
RB9844
Hypothetical protein-putative transmembrane protein.
       0.593
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
       0.593
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
      
 0.544
RB6417
Conserved hypothetical protein-putative FHA domain; PMID: 9634230 PMID: 7482699 best DB hits: BLAST: pir:B70700; hypothetical protein Rv0020c - Mycobacterium; E=8e-06 pir:T10015; hypothetical protein MLB1770.15c - Mycobacterium leprae; E=4e-05 ddbj:BAB20624.1; (AB052847) adenylate cyclase; E=0.001 COG: Rv0020c_2; COG1716 FHA-domain-containing proteins; E=4e-06 PFAM: PF00498; FHA domain; E=8.9e-17.
  
 
 
 0.542
comE
PMID: 7968523 best DB hits: BLAST: pir:B75346; probable competence protein ComECRec2 - Deinococcus; E=2e-19 ddbj:BAA12454.1; (D84432) ComEC [Bacillus subtilis] -----; E=3e-19 swissprot:P39695; CME3_BACSU COME OPERON PROTEIN 3 ----- pir:; E=1e-18 COG: DR1854_2; COG2333 Predicted hydrolases of metallo-beta-lactamase; E=3e-16 BH1335_1; COG0658 Predicted multitransmembrane, metal-binding; E=5e-13 PA2984_2; COG2333 Predicted hydrolases of metallo-beta-lactamase; E=5e-09 PFAM: PF00753; Metallo-beta-lactamase superfamil; E=1.5e-07.
       0.511
RB1789
PMID: 10484179 best DB hits: BLAST: ddbj:BAB05496.1; (AP001513) BH1777~unknown conserved protein; E=1e-04 ddbj:BAA14001.1; (D89626) adenylate cyclase [Anabaena sp.]; E=0.001 pir:B70700; hypothetical protein Rv0020c - Mycobacterium; E=0.003 COG: BH1777_1; COG1716 FHA-domain-containing proteins; E=5e-05 PFAM: PF00498; FHA domain; E=4.6e-18.
  
 
 
 0.495
Your Current Organism:
Rhodopirellula baltica
NCBI taxonomy Id: 243090
Other names: Pirellula sp. 1, R. baltica SH 1, Rhodopirellula baltica SH 1, Rhodopirellula baltica str. SH 1, Rhodopirellula baltica strain SH 1
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