node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DR_0001 | DR_1289 | DR_0001 | DR_1289 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA helicase RecQ; Similar to GB:M87049 SP:P15043 GB:M30198 PID:147559 PID:148221 percent identity: 65.38; identified by sequence similarity; putative. | 0.540 |
DR_0001 | DR_1775 | DR_0001 | DR_1775 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA helicase II; Similar to GB:M87049 SP:P03018 GB:D00069 GB:X00225 GB:X00738 percent identity: 61.60; identified by sequence similarity; putative. | 0.880 |
DR_0001 | ligA | DR_0001 | DR_2069 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | 0.400 |
DR_0001 | mutL | DR_0001 | DR_1696 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.942 |
DR_0001 | polA | DR_0001 | DR_1707 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA-directed DNA polymerase; A DNA polymerase, required for DNA repair after DNA damage induced by ionizing radiation (IR); this is not the major DNA polymerase. Following severe irradiation (7 kGy of gamma irradiation) genomic DNA is fragmented. DNA is progressively degraded for the first 1.5 hours after IR, in a step promoted by RecA and counterbalanced by DNA Pol I and Pol III, followed by massive DNA synthesis and genome reassembly in the next hour. Optimal priming of DNA synthesis requires both RecA and RadA, Pol III initiates DNA synthesis while both Pol I and Pol III are require [...] | 0.998 |
DR_0001 | recA | DR_0001 | DR_2340 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity). Probably involved in base excision repair ; Belongs to the RecA family. | 0.851 |
DR_0001 | topA | DR_0001 | DR_1374 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.693 |
DR_1289 | DR_0001 | DR_1289 | DR_0001 | DNA helicase RecQ; Similar to GB:M87049 SP:P15043 GB:M30198 PID:147559 PID:148221 percent identity: 65.38; identified by sequence similarity; putative. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.540 |
DR_1289 | DR_1775 | DR_1289 | DR_1775 | DNA helicase RecQ; Similar to GB:M87049 SP:P15043 GB:M30198 PID:147559 PID:148221 percent identity: 65.38; identified by sequence similarity; putative. | DNA helicase II; Similar to GB:M87049 SP:P03018 GB:D00069 GB:X00225 GB:X00738 percent identity: 61.60; identified by sequence similarity; putative. | 0.797 |
DR_1289 | mutL | DR_1289 | DR_1696 | DNA helicase RecQ; Similar to GB:M87049 SP:P15043 GB:M30198 PID:147559 PID:148221 percent identity: 65.38; identified by sequence similarity; putative. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.646 |
DR_1289 | polA | DR_1289 | DR_1707 | DNA helicase RecQ; Similar to GB:M87049 SP:P15043 GB:M30198 PID:147559 PID:148221 percent identity: 65.38; identified by sequence similarity; putative. | DNA-directed DNA polymerase; A DNA polymerase, required for DNA repair after DNA damage induced by ionizing radiation (IR); this is not the major DNA polymerase. Following severe irradiation (7 kGy of gamma irradiation) genomic DNA is fragmented. DNA is progressively degraded for the first 1.5 hours after IR, in a step promoted by RecA and counterbalanced by DNA Pol I and Pol III, followed by massive DNA synthesis and genome reassembly in the next hour. Optimal priming of DNA synthesis requires both RecA and RadA, Pol III initiates DNA synthesis while both Pol I and Pol III are require [...] | 0.872 |
DR_1289 | recA | DR_1289 | DR_2340 | DNA helicase RecQ; Similar to GB:M87049 SP:P15043 GB:M30198 PID:147559 PID:148221 percent identity: 65.38; identified by sequence similarity; putative. | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity). Probably involved in base excision repair ; Belongs to the RecA family. | 0.802 |
DR_1289 | topA | DR_1289 | DR_1374 | DNA helicase RecQ; Similar to GB:M87049 SP:P15043 GB:M30198 PID:147559 PID:148221 percent identity: 65.38; identified by sequence similarity; putative. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.848 |
DR_1775 | DR_0001 | DR_1775 | DR_0001 | DNA helicase II; Similar to GB:M87049 SP:P03018 GB:D00069 GB:X00225 GB:X00738 percent identity: 61.60; identified by sequence similarity; putative. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.880 |
DR_1775 | DR_1289 | DR_1775 | DR_1289 | DNA helicase II; Similar to GB:M87049 SP:P03018 GB:D00069 GB:X00225 GB:X00738 percent identity: 61.60; identified by sequence similarity; putative. | DNA helicase RecQ; Similar to GB:M87049 SP:P15043 GB:M30198 PID:147559 PID:148221 percent identity: 65.38; identified by sequence similarity; putative. | 0.797 |
DR_1775 | DR_A0188 | DR_1775 | DR_A0188 | DNA helicase II; Similar to GB:M87049 SP:P03018 GB:D00069 GB:X00225 GB:X00738 percent identity: 61.60; identified by sequence similarity; putative. | Excinuclease ABC, subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. Belongs to the ABC transporter superfamily. UvrA family. | 0.815 |
DR_1775 | ligA | DR_1775 | DR_2069 | DNA helicase II; Similar to GB:M87049 SP:P03018 GB:D00069 GB:X00225 GB:X00738 percent identity: 61.60; identified by sequence similarity; putative. | DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | 0.761 |
DR_1775 | mutL | DR_1775 | DR_1696 | DNA helicase II; Similar to GB:M87049 SP:P03018 GB:D00069 GB:X00225 GB:X00738 percent identity: 61.60; identified by sequence similarity; putative. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.803 |
DR_1775 | polA | DR_1775 | DR_1707 | DNA helicase II; Similar to GB:M87049 SP:P03018 GB:D00069 GB:X00225 GB:X00738 percent identity: 61.60; identified by sequence similarity; putative. | DNA-directed DNA polymerase; A DNA polymerase, required for DNA repair after DNA damage induced by ionizing radiation (IR); this is not the major DNA polymerase. Following severe irradiation (7 kGy of gamma irradiation) genomic DNA is fragmented. DNA is progressively degraded for the first 1.5 hours after IR, in a step promoted by RecA and counterbalanced by DNA Pol I and Pol III, followed by massive DNA synthesis and genome reassembly in the next hour. Optimal priming of DNA synthesis requires both RecA and RadA, Pol III initiates DNA synthesis while both Pol I and Pol III are require [...] | 0.761 |
DR_1775 | recA | DR_1775 | DR_2340 | DNA helicase II; Similar to GB:M87049 SP:P03018 GB:D00069 GB:X00225 GB:X00738 percent identity: 61.60; identified by sequence similarity; putative. | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity). Probably involved in base excision repair ; Belongs to the RecA family. | 0.912 |