STRINGSTRING
ABK74300.1 ABK74300.1 aroC aroC ABK71789.1 ABK71789.1 ABK71866.1 ABK71866.1 pheA pheA ABK75279.1 ABK75279.1 trpE trpE ABK69697.1 ABK69697.1 ABK69759.1 ABK69759.1 aroG aroG ABK75414.1 ABK75414.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ABK74300.1Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. May play some role in the pathogenicity. (181 aa)    
Predicted Functional Partners:
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
  
 
 0.966
ABK71789.1
Prephenate dehydrogenase; Identified by match to protein family HMM PF02153.
  
 0.952
ABK71866.1
Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis.
     
 0.941
pheA
Prephenate dehydratase; Identified by match to protein family HMM PF00800; match to protein family HMM PF01842.
  
 
 0.926
ABK75279.1
Cyclohexadienyl dehydratase; Identified by match to protein family HMM PF00497.
 
 
 0.919
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
  
 
 0.916
ABK69697.1
Isochorismate synthase DhbC; Identified by match to protein family HMM PF00425; match to protein family HMM TIGR00543.
  
 
 0.910
ABK69759.1
Anthranilate synthase component 2; Identified by match to protein family HMM PF00117; match to protein family HMM TIGR00566.
  
 
 0.897
aroG
3-deoxy-7-phosphoheptulonate synthase; Catalyzes an aldol-like condensation reaction between phosphoenolpyruvate (PEP) and D-erythrose 4-phosphate (E4P) to generate 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAH7P) and inorganic phosphate.
  
 
 0.845
ABK75414.1
Anthranilate synthase component I; Identified by match to protein family HMM PF00425.
  
 
 0.845
Your Current Organism:
Mycolicibacterium smegmatis
NCBI taxonomy Id: 246196
Other names: M. smegmatis MC2 155, Mycobacterium smegmatis MC2 155, Mycolicibacterium smegmatis MC2 155
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