node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK69912.1 | ABK73957.1 | MSMEG_4305 | MSMEG_5849 | Phosphoglycerate mutase; Identified by match to protein family HMM PF00300. | Conserved hypothetical protein; Identified by match to protein family HMM PF04607. | 0.768 |
ABK69912.1 | dnaN | MSMEG_4305 | MSMEG_0001 | Phosphoglycerate mutase; Identified by match to protein family HMM PF00300. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.431 |
ABK69912.1 | polA | MSMEG_4305 | MSMEG_3839 | Phosphoglycerate mutase; Identified by match to protein family HMM PF00300. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.710 |
ABK69912.1 | rnhA | MSMEG_4305 | MSMEG_5562 | Phosphoglycerate mutase; Identified by match to protein family HMM PF00300. | RNase H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.955 |
ABK69912.1 | rnhB | MSMEG_4305 | MSMEG_2442 | Phosphoglycerate mutase; Identified by match to protein family HMM PF00300. | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.954 |
ABK73957.1 | ABK69912.1 | MSMEG_5849 | MSMEG_4305 | Conserved hypothetical protein; Identified by match to protein family HMM PF04607. | Phosphoglycerate mutase; Identified by match to protein family HMM PF00300. | 0.768 |
ABK73957.1 | rnhB | MSMEG_5849 | MSMEG_2442 | Conserved hypothetical protein; Identified by match to protein family HMM PF04607. | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.854 |
ABK73959.1 | lepB | MSMEG_2443 | MSMEG_2441 | Conserved hypothetical protein. | Signal peptidase I; Identified by match to protein family HMM PF00717; match to protein family HMM TIGR02227; Belongs to the peptidase S26 family. | 0.796 |
ABK73959.1 | rnhB | MSMEG_2443 | MSMEG_2442 | Conserved hypothetical protein. | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.800 |
ABK73959.1 | rplS | MSMEG_2443 | MSMEG_2440 | Conserved hypothetical protein. | Ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. | 0.579 |
ABK74760.1 | dnaN | MSMEG_2469 | MSMEG_0001 | AMP-dependent synthetase and ligase; Identified by match to protein family HMM PF00501; match to protein family HMM PF00550. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.573 |
ABK74760.1 | polA | MSMEG_2469 | MSMEG_3839 | AMP-dependent synthetase and ligase; Identified by match to protein family HMM PF00501; match to protein family HMM PF00550. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.683 |
ABK74760.1 | rnhB | MSMEG_2469 | MSMEG_2442 | AMP-dependent synthetase and ligase; Identified by match to protein family HMM PF00501; match to protein family HMM PF00550. | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.755 |
ABK74760.1 | rplS | MSMEG_2469 | MSMEG_2440 | AMP-dependent synthetase and ligase; Identified by match to protein family HMM PF00501; match to protein family HMM PF00550. | Ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. | 0.623 |
dnaN | ABK69912.1 | MSMEG_0001 | MSMEG_4305 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Phosphoglycerate mutase; Identified by match to protein family HMM PF00300. | 0.431 |
dnaN | ABK74760.1 | MSMEG_0001 | MSMEG_2469 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | AMP-dependent synthetase and ligase; Identified by match to protein family HMM PF00501; match to protein family HMM PF00550. | 0.573 |
dnaN | polA | MSMEG_0001 | MSMEG_3839 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.995 |
dnaN | rnhB | MSMEG_0001 | MSMEG_2442 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.894 |
dnaN | thyA | MSMEG_0001 | MSMEG_2670 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.793 |
lepB | ABK73959.1 | MSMEG_2441 | MSMEG_2443 | Signal peptidase I; Identified by match to protein family HMM PF00717; match to protein family HMM TIGR02227; Belongs to the peptidase S26 family. | Conserved hypothetical protein. | 0.796 |