node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SPO2469 | SPO3203 | SPO2469 | SPO3203 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase, putative; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.933 |
SPO2469 | SPO3455 | SPO2469 | SPO3455 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | Adenylate/guanylate cyclase; Identified by match to protein family HMM PF00211; match to protein family HMM PF04248. | 0.900 |
SPO2469 | cpdA | SPO2469 | SPO1176 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | Ser/Thr protein phosphatase family protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | 0.900 |
SPO2469 | cpdA-2 | SPO2469 | SPO1819 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | Phosphodiesterase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | 0.900 |
SPO2469 | folE2 | SPO2469 | SPO1352 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | Hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. | 0.800 |
SPO2469 | moaA-2 | SPO2469 | SPO2799 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | 0.805 |
SPO2469 | ndk | SPO2469 | SPO2444 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.900 |
SPO2469 | pyk | SPO2469 | SPO3600 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | Pyruvate kinase; Identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. | 0.900 |
SPO2469 | ribB | SPO2469 | SPO1761 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II, putative; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.832 |
SPO2469 | ribBA | SPO2469 | SPO3427 | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. | 0.802 |
SPO3203 | SPO2469 | SPO3203 | SPO2469 | guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase, putative; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | 0.933 |
SPO3203 | SPO3455 | SPO3203 | SPO3455 | guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase, putative; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Adenylate/guanylate cyclase; Identified by match to protein family HMM PF00211; match to protein family HMM PF04248. | 0.900 |
SPO3203 | folE2 | SPO3203 | SPO1352 | guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase, putative; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. | 0.800 |
SPO3203 | moaA-2 | SPO3203 | SPO2799 | guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase, putative; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. | 0.813 |
SPO3203 | ndk | SPO3203 | SPO2444 | guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase, putative; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.920 |
SPO3203 | pyk | SPO3203 | SPO3600 | guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase, putative; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | Pyruvate kinase; Identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. | 0.909 |
SPO3203 | ribB | SPO3203 | SPO1761 | guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase, putative; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II, putative; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.848 |
SPO3203 | ribBA | SPO3203 | SPO3427 | guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase, putative; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. | 0.815 |
SPO3455 | SPO2469 | SPO3455 | SPO2469 | Adenylate/guanylate cyclase; Identified by match to protein family HMM PF00211; match to protein family HMM PF04248. | Identified by match to protein family HMM PF03819; match to protein family HMM TIGR00444. | 0.900 |
SPO3455 | SPO3203 | SPO3455 | SPO3203 | Adenylate/guanylate cyclase; Identified by match to protein family HMM PF00211; match to protein family HMM PF04248. | guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase, putative; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.900 |