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hemL hemL hemB hemB hemA hemA DIP0411 DIP0411 hemE hemE DIP0412 DIP0412 DIP0410 DIP0410 hemC hemC DIP2189 DIP2189 DIP0414 DIP0414 ctaE ctaE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
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Cooccurrence
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[Homology]
Score
hemLSimilar to Streptomyces coelicolor glutamate-1-semialdehyde 2,1-aminomutase HemL or SCD65.12 SW:GSA_STRCO (Q9F2S0) (438 aa) fasta scores: E(): 4e-96, 62.97% id in 424 aa, and to Escherichia coli glutamate-1-semialdehyde 2,1-aminomutase HemL or Gsa or PopC or B0154 SW:GSA_ECOLI (P23893) (426 aa) fasta scores: E(): 1.7e-75, 52.39% id in 418 aa. (430 aa)    
Predicted Functional Partners:
hemB
Similar to Streptomyces coelicolor delta-aminolevulinic acid dehydratase HemB or SCE68.09c SW:HEM2_STRCO (P54919) (330 aa) fasta scores: E(): 4.2e-76, 62.84% id in 323 aa, and to Escherichia coli delta-aminolevulinic acid dehydratase HemB or Ncf or B0369 SW:HEM2_ECOLI (P15002) (323 aa) fasta scores: E(): 3.6e-57, 50% id in 326 aa; Belongs to the ALAD family.
 
 
 0.999
hemA
Putative glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.998
DIP0411
Putative electron transport related protein; Similar to Deinococcus radiodurans thiol:disulfide interchange protein DR0189 TR:Q9RXW6 (EMBL:AE001881) (185 aa) fasta scores: E(): 7.1e-09, 34.84% id in 132 aa, and to Bacillus halodurans thioredoxin BH1522 TR:Q9KCP7 (EMBL:AP001512) (177 aa) fasta scores: E(): 3.4e-08, 34.12% id in 126 aa and to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT0548 TR:AAK44771 (EMBL:AE006954) (216 aa) fasta scores: E(): 9.2e-31, 48.95% id in 192 aa.
  
  
 0.993
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
  
 0.981
DIP0412
Putative cytochrome C biogenesis protein; Similar to Mycobacterium leprae B2168_C1_192 ML2411 TR:Q49810 (EMBL:U00018) (262 aa) fasta scores: E(): 8.6e-46, 53.2% id in 250 aa.
  
  
 0.980
DIP0410
Similar to Streptomyces coelicolor putative phosphoglycerate mutase SCD65.13 TR:Q9F2R9 (EMBL:AL392176) (233 aa) fasta scores: E(): 1.5e-35, 50.25% id in 199 aa and low similarity to Escherichia coli probable phosphoglycerate mutase 2 GpmB or B4395 or Z5997 or ECS5353 SW:PMG2_ECOLI (P36942) (215 aa) fasta scores: E(): 8.5e-06, 25.96% id in 181 aa.
  
    0.958
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
  
 0.943
DIP2189
Putative polyketide synthase; Similar to Mycobacterium tuberculosis polyketide synthase PKS13 or Rv3800c or MTV026.05c TR:O53579 (EMBL:AL022076) (1733 aa) fasta scores: E(): 5.4e-109, 44.5% id in 1719 aa, and to Polyangium cellulosum soraphen polyketide synthase A SorA TR:Q9ADL6 (EMBL:U24241) (6315 aa) fasta scores: E(): 6.2e-101, 35.96% id in 1090 aa.
    
 0.941
DIP0414
Putative cytochrome C related protein; Similar to Mycobacterium tuberculosis CDC1551 cytochrome C assembly family protein MT0551 TR:AAK44774 (EMBL:AE006954) (324 aa) fasta scores: E(): 6.3e-54, 47.81% id in 320 aa.
 
  
 0.908
ctaE
Similar to Corynebacterium glutamicum cytochrome AA3 oxidase subunit III CtaE TR:Q9AEL8 (EMBL:AJ306418) (205 aa) fasta scores: E(): 9.9e-67, 81.95% id in 205 aa, and to Mycobacterium tuberculosis probable cytochrome C oxidase polypeptide III CtaE or Rv2193 or MT2249 or MTCY190.04 SW:COX3_MYCTU (Q10385) (203 aa) fasta scores: E(): 3.6e-47, 60% id in 205 aa.
      
 0.878
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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