node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mbur_0967 | hisA | Mbur_0967 | Mbur_1332 | Nucleoside kinase; Evidence code ER2; Belongs to the carbohydrate kinase PfkB family. | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; Evidence code ER2. | 0.842 |
Mbur_1675 | hisA | Mbur_1675 | Mbur_1332 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Evidence code ER4; Belongs to the HisA/HisF family. | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; Evidence code ER2. | 0.930 |
Mbur_1675 | hisF | Mbur_1675 | Mbur_1857 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Evidence code ER4; Belongs to the HisA/HisF family. | Imidazoleglycerol-phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.922 |
Mbur_1675 | hisH | Mbur_1675 | Mbur_1801 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Evidence code ER4; Belongs to the HisA/HisF family. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.900 |
Mbur_1675 | hisI | Mbur_1675 | Mbur_1790 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Evidence code ER4; Belongs to the HisA/HisF family. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.900 |
hisA | Mbur_0967 | Mbur_1332 | Mbur_0967 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; Evidence code ER2. | Nucleoside kinase; Evidence code ER2; Belongs to the carbohydrate kinase PfkB family. | 0.842 |
hisA | Mbur_1675 | Mbur_1332 | Mbur_1675 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; Evidence code ER2. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Evidence code ER4; Belongs to the HisA/HisF family. | 0.930 |
hisA | hisB | Mbur_1332 | Mbur_1333 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; Evidence code ER2. | Imidazoleglycerol-phosphate dehydratase; Evidence code ER2. | 0.997 |
hisA | hisC | Mbur_1332 | Mbur_2203 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; Evidence code ER2. | Histidinol-phosphate aminotransferase; Evidence code ER2. | 0.839 |
hisA | hisD | Mbur_1332 | Mbur_1103 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; Evidence code ER2. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.994 |
hisA | hisE | Mbur_1332 | Mbur_1885 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; Evidence code ER2. | Phosphoribosyl-ATP pyrophosphatase; Evidence code ER2. | 0.988 |
hisA | hisF | Mbur_1332 | Mbur_1857 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; Evidence code ER2. | Imidazoleglycerol-phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.998 |
hisA | hisG | Mbur_1332 | Mbur_1331 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; Evidence code ER2. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.996 |
hisA | hisH | Mbur_1332 | Mbur_1801 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; Evidence code ER2. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | Mbur_1332 | Mbur_1790 | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; Evidence code ER2. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisB | hisA | Mbur_1333 | Mbur_1332 | Imidazoleglycerol-phosphate dehydratase; Evidence code ER2. | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; Evidence code ER2. | 0.997 |
hisB | hisC | Mbur_1333 | Mbur_2203 | Imidazoleglycerol-phosphate dehydratase; Evidence code ER2. | Histidinol-phosphate aminotransferase; Evidence code ER2. | 0.998 |
hisB | hisD | Mbur_1333 | Mbur_1103 | Imidazoleglycerol-phosphate dehydratase; Evidence code ER2. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisE | Mbur_1333 | Mbur_1885 | Imidazoleglycerol-phosphate dehydratase; Evidence code ER2. | Phosphoribosyl-ATP pyrophosphatase; Evidence code ER2. | 0.985 |
hisB | hisF | Mbur_1333 | Mbur_1857 | Imidazoleglycerol-phosphate dehydratase; Evidence code ER2. | Imidazoleglycerol-phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |