STRINGSTRING
lipA lipA lipB lipB Rxyl_0450 Rxyl_0450 Rxyl_0957 Rxyl_0957 gcvH gcvH Rxyl_2549 Rxyl_2549 Rxyl_2478 Rxyl_2478 Rxyl_0350 Rxyl_0350 Rxyl_2534 Rxyl_2534 Rxyl_2551 Rxyl_2551 guaA guaA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (321 aa)    
Predicted Functional Partners:
lipB
Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
 
 0.999
Rxyl_0450
PFAM: biotin/lipoate A/B protein ligase; KEGG: bbr:BB2891 putative lipoate-protein ligase A.
  
 
 0.922
Rxyl_0957
PFAM: biotin/lipoate A/B protein ligase; KEGG: hal:VNG2536C hypothetical protein.
  
 
 0.917
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 
 0.904
Rxyl_2549
TIGRFAM: Dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase glucose-inhibited division protein A pyridine nucleotide-disulphide oxidoreductase dimerisation region HI0933-like protein FAD dependent oxidoreductase; KEGG: gka:GK2379 dihydrolipoamide dehydrogenase.
 
  
 0.756
Rxyl_2478
Branched-chain alpha-keto acid dehydrogenase E2 component; PFAM: biotin/lipoyl attachment catalytic domain of components of various dehydrogenase complexes E3 binding; KEGG: sth:STH2160 branched-chain alpha-keto acid dehydrogenase E2.
 
  
 0.559
Rxyl_0350
PFAM: biotin/lipoyl attachment catalytic domain of components of various dehydrogenase complexes E3 binding; KEGG: tfu:Tfu_3051 pyruvate dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase.
 
  
 0.505
Rxyl_2534
2-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 
  
 0.504
Rxyl_2551
PFAM: TENA/THI-4 protein; KEGG: mag:amb2534 hypothetical protein.
     
 0.496
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
     
 0.494
Your Current Organism:
Rubrobacter xylanophilus
NCBI taxonomy Id: 266117
Other names: R. xylanophilus DSM 9941, Rubrobacter xylanophilus DSM 9941, Rubrobacter xylanophilus str. DSM 9941, Rubrobacter xylanophilus strain DSM 9941
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