node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GcvT | Rru_A1146 | Rru_A3051 | Rru_A1146 | Glycine cleavage system T protein. | 5-aminolevulinate synthase. | 0.511 |
GcvT | Rru_A1215 | Rru_A3051 | Rru_A1215 | Glycine cleavage system T protein. | Dihydrolipoamide dehydrogenase. | 0.963 |
GcvT | Rru_A1878 | Rru_A3051 | Rru_A1878 | Glycine cleavage system T protein. | Dihydrolipoamide dehydrogenase. | 0.960 |
GcvT | Rru_A2508 | Rru_A3051 | Rru_A2508 | Glycine cleavage system T protein. | 5-aminolevulinate synthase. | 0.511 |
GcvT | Rru_A3048 | Rru_A3051 | Rru_A3048 | Glycine cleavage system T protein. | Glycine dehydrogenase (decarboxylating) beta subunit. | 0.999 |
GcvT | gcvH | Rru_A3051 | Rru_A3050 | Glycine cleavage system T protein. | Glycine cleavage H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
GcvT | gcvPA | Rru_A3051 | Rru_A3049 | Glycine cleavage system T protein. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.999 |
GcvT | glyA1 | Rru_A3051 | Rru_A1142 | Glycine cleavage system T protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.996 |
GcvT | glyA2 | Rru_A3051 | Rru_A1827 | Glycine cleavage system T protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.996 |
Rru_A1146 | GcvT | Rru_A1146 | Rru_A3051 | 5-aminolevulinate synthase. | Glycine cleavage system T protein. | 0.511 |
Rru_A1146 | Rru_A2249 | Rru_A1146 | Rru_A2249 | 5-aminolevulinate synthase. | L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. | 0.912 |
Rru_A1146 | Rru_A2508 | Rru_A1146 | Rru_A2508 | 5-aminolevulinate synthase. | 5-aminolevulinate synthase. | 0.903 |
Rru_A1146 | Rru_A3048 | Rru_A1146 | Rru_A3048 | 5-aminolevulinate synthase. | Glycine dehydrogenase (decarboxylating) beta subunit. | 0.915 |
Rru_A1146 | gcvPA | Rru_A1146 | Rru_A3049 | 5-aminolevulinate synthase. | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.912 |
Rru_A1146 | glyA1 | Rru_A1146 | Rru_A1142 | 5-aminolevulinate synthase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.937 |
Rru_A1146 | glyA2 | Rru_A1146 | Rru_A1827 | 5-aminolevulinate synthase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.911 |
Rru_A1215 | GcvT | Rru_A1215 | Rru_A3051 | Dihydrolipoamide dehydrogenase. | Glycine cleavage system T protein. | 0.963 |
Rru_A1215 | Rru_A1878 | Rru_A1215 | Rru_A1878 | Dihydrolipoamide dehydrogenase. | Dihydrolipoamide dehydrogenase. | 0.910 |
Rru_A1215 | Rru_A3048 | Rru_A1215 | Rru_A3048 | Dihydrolipoamide dehydrogenase. | Glycine dehydrogenase (decarboxylating) beta subunit. | 0.944 |
Rru_A1215 | gcvH | Rru_A1215 | Rru_A3050 | Dihydrolipoamide dehydrogenase. | Glycine cleavage H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.990 |