STRINGSTRING
Tfu_0853 Tfu_0853 Tfu_0456 Tfu_0456 recO recO Tfu_0680 Tfu_0680 dxr dxr Tfu_0854 Tfu_0854 Tfu_2681 Tfu_2681 Tfu_1051 Tfu_1051 frr frr proS proS pnp pnp
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Tfu_0853Undecaprenyl pyrophosphate synthetase; Catalyzes the synthesis of Z,E-mixed prenyl diphosphates by a condensation of isopentenyl diphosphate to an allylic diphosphate. It shows a large substrate specificity accepting dimethylallyl diphosphate (DMAPP), GPP, E,Efarnesyl diphosphate (FPP), E,E,E-geranylgeranyl diphosphate (GGPP), neryl diphosphate (Z-GPP), and (2Z,6E)-farnesyl diphosphate (Z,E-FPP) as allylic substrates. The enzyme exhibits the highest activity when Z,E-FPP is employed as an allylic substrate. The major product is dodecaprenyl diphosphate (C60) under every allylic substra [...] (282 aa)    
Predicted Functional Partners:
Tfu_0456
Undecaprenyl pyrophosphate synthetase; Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carbon product (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP). Only geranyl diphosphate (GPP) can be used as isoprenyl acceptor.
  
  
 
0.915
recO
Recombination protein O, RecO; Involved in DNA repair and RecF pathway recombination.
  
  
 0.893
Tfu_0680
Phosphatidate cytidylyltransferase.
 
  
 0.871
dxr
1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family.
  
  
 0.868
Tfu_0854
Conserved hypothetical protein.
  
    0.773
Tfu_2681
Trans-hexaprenyltranstransferase; Belongs to the FPP/GGPP synthase family.
 
  
 0.771
Tfu_1051
Putative polyprenyl synthase / dimethylallyltranstransferase; Belongs to the FPP/GGPP synthase family.
 
  
 0.721
frr
Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.
 
  
 0.696
proS
prolyl-tRNA synthetase, bacterial; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and i [...]
  
    0.649
pnp
Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.
 
    0.638
Your Current Organism:
Thermobifida fusca
NCBI taxonomy Id: 269800
Other names: T. fusca YX, Thermobifida fusca YX, Thermobifida fusca str. YX, Thermobifida fusca strain YX
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