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sucD sucD sucC sucC sdhB sdhB sdhA sdhA sdhC sdhC pdhC pdhC sdhD sdhD APE_1686.1 APE_1686.1 APE_1687 APE_1687 prpB prpB APE_1472 APE_1472
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
sucDsuccinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (292 aa)    
Predicted Functional Partners:
sucC
succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.999
sdhB
Succinate dehydrogenase subunit B.
 
 0.993
sdhA
Succinate dehydrogenase subunit A.
 
 0.993
sdhC
Succinate dehydrogenase subunit C.
  
 
 0.990
pdhC
Pyruvate dehydrogenase complex, E2 component; Dihydrolipoyllysine-residue acetyltransferase component.
 
 0.987
sdhD
Putative succinate dehydrogenase subunit D.
  
 
 0.966
APE_1686.1
Coenzyme B12-dependent mutase.
    
 0.942
APE_1687
Coenzyme B12-dependent mutase.
    
 0.938
prpB
Putative carboxyvinyl-carboxyphosphonate phosphorylmutase; Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2- methylisocitrate to yield pyruvate and succinate via an alpha-carboxy- carbanion intermediate.
   
 0.937
APE_1472
2-oxoacid:ferredoxin oxidoreductase beta subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives.
  
 
 0.937
Your Current Organism:
Aeropyrum pernix
NCBI taxonomy Id: 272557
Other names: A. pernix K1, Aeropyrum pernix K1, Aeropyrum pernix str. K1, Aeropyrum pernix strain K1
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