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hemA hemA hemL-2 hemL-2 hemC hemC hemL hemL hemB hemB gltX gltX cobA cobA APE_0072 APE_0072 APE_2295.1 APE_2295.1 cobS cobS sirC sirC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (416 aa)    
Predicted Functional Partners:
hemL-2
Glutamate-1-semialdehyde aminotransferase; GSA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
 
 0.999
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
  
 0.997
hemL
Glutamate-1-semialdehyde aminotransferase; GSA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
 
 0.995
hemB
Porphobilinogen synthase; ALADH; delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
  
 0.939
gltX
glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
     
 0.922
cobA
uroporphyrin-III C-methyltransferase; SUMT; Belongs to the precorrin methyltransferase family.
  
  
 0.727
APE_0072
Heme exporter protein C.
  
  
 0.710
APE_2295.1
Conserved hypothetical protein.
       0.605
cobS
Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
     
 0.596
sirC
Precorrin-2 dehydrogenase.
 
   
 0.589
Your Current Organism:
Aeropyrum pernix
NCBI taxonomy Id: 272557
Other names: A. pernix K1, Aeropyrum pernix K1, Aeropyrum pernix str. K1, Aeropyrum pernix strain K1
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