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panB panB panC panC panD panD CA_C2937 CA_C2937 ilvE ilvE ilvD ilvD ilvD-2 ilvD-2 CA_C2226 CA_C2226 thiG thiG tenI tenI nadD nadD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
panBKetopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (276 aa)    
Predicted Functional Partners:
panC
Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
  
 0.999
panD
Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
 
  
 0.996
CA_C2937
Ketopantoate reductase PanE/ApbA; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
   
 0.986
ilvE
Branched-chain-amino-acid transaminase (ilvE).
  
 
 0.915
ilvD
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
     
 0.915
ilvD-2
Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family.
     
 0.915
CA_C2226
Enzyme of ILVE/PABC family (branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase).
    
 0.913
thiG
Uncharacterized enzyme of thiazol biosynthesis; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
     
 0.775
tenI
Thiamine monophosphate synthase.
     
 0.759
nadD
Predicted nucleotidyltransferases of NarD/TagD family (N-term. domain), yqeJ ortholog; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
      
 0.757
Your Current Organism:
Clostridium acetobutylicum
NCBI taxonomy Id: 272562
Other names: C. acetobutylicum ATCC 824, Clostridium acetobutylicum ATCC 824, Clostridium acetobutylicum DSM 792, Clostridium acetobutylicum str. ATCC 824, Clostridium acetobutylicum strain ATCC 824
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