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KPN_02060 KPN_02060 KPN_02059 KPN_02059 ilvH ilvH ilvN ilvN ilvC ilvC ydbK ydbK leuB leuB tdcB tdcB leuA leuA maeB maeB KPN_01015 KPN_01015
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query proteins and first shell of interactors
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second shell of interactors
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experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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KPN_02060Acetolactate synthase large subunit; Belongs to the TPP enzyme family. (559 aa)    
Predicted Functional Partners:
KPN_02059
Acetolactate decarboxylase; Belongs to the alpha-acetolactate decarboxylase family.
 
 
 0.995
ilvH
Acetolactate synthase small subunit.
 
 0.978
ilvN
Acetolactate synthase small subunit.
  
 0.965
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.941
ydbK
Putative oxidoreductase, Fe-S subunit.
  
 
 0.856
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 0.845
tdcB
Threonine dehydratase.
 
 0.826
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 
 0.811
maeB
Phosphate acetyltransferase.
  
 
 0.808
KPN_01015
Putative tartrate dehydrogenase.
 
 0.787
Your Current Organism:
Klebsiella pneumoniae MGH78578
NCBI taxonomy Id: 272620
Other names: K. pneumoniae subsp. pneumoniae MGH 78578, Klebsiella pneumoniae MCG 78578, Klebsiella pneumoniae str. MCG 78578, Klebsiella pneumoniae subsp. pneumoniae ATCC 700721, Klebsiella pneumoniae subsp. pneumoniae MGH 78578, Klebsiella pneumoniae subsp. pneumoniae str. MGH 78578, Klebsiella pneumoniae subsp. pneumoniae strain MGH 78578
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