node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dnaK | legA8 | lpg2025 | lpg0695 | Chaperone protein DnaK, heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Ankyrin repeat-containing protein; Virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). Acts as a phosphocholine transferase by mediating the addition of phosphocholine to Ser residues of host RAB1 (RAB1A, RAB1B or RAB1C) and RAB35, leading to displacement of GDP dissociation inhibitors (GDI). Phosphocholination of target proteins also impairs accessibility to GTPase effector LepB. Can act on both GDP-bound and GTP-bound Rab proteins. | 0.975 |
dnaK | legS2 | lpg2025 | lpg2176 | Chaperone protein DnaK, heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Sphingosine-1-phosphate lyase I; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine (By similarity). Possibly implicated in influencing the macrophage autophagy pathway. | 0.825 |
dnaK | lpg2423 | lpg2025 | lpg2423 | Chaperone protein DnaK, heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Hypothetical protein-transmembrane region and signal peptide prediction. | 0.965 |
dnaK | lpg2911 | lpg2025 | lpg2911 | Chaperone protein DnaK, heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Serine carboxypeptidase. | 0.421 |
dnaK | pksJ | lpg2025 | lpg2186 | Chaperone protein DnaK, heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Polyketide synthase, type I. | 0.572 |
legA8 | dnaK | lpg0695 | lpg2025 | Ankyrin repeat-containing protein; Virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). Acts as a phosphocholine transferase by mediating the addition of phosphocholine to Ser residues of host RAB1 (RAB1A, RAB1B or RAB1C) and RAB35, leading to displacement of GDP dissociation inhibitors (GDI). Phosphocholination of target proteins also impairs accessibility to GTPase effector LepB. Can act on both GDP-bound and GTP-bound Rab proteins. | Chaperone protein DnaK, heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.975 |
legA8 | legS2 | lpg0695 | lpg2176 | Ankyrin repeat-containing protein; Virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). Acts as a phosphocholine transferase by mediating the addition of phosphocholine to Ser residues of host RAB1 (RAB1A, RAB1B or RAB1C) and RAB35, leading to displacement of GDP dissociation inhibitors (GDI). Phosphocholination of target proteins also impairs accessibility to GTPase effector LepB. Can act on both GDP-bound and GTP-bound Rab proteins. | Sphingosine-1-phosphate lyase I; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine (By similarity). Possibly implicated in influencing the macrophage autophagy pathway. | 0.743 |
legA8 | lpg0521 | lpg0695 | lpg0521 | Ankyrin repeat-containing protein; Virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). Acts as a phosphocholine transferase by mediating the addition of phosphocholine to Ser residues of host RAB1 (RAB1A, RAB1B or RAB1C) and RAB35, leading to displacement of GDP dissociation inhibitors (GDI). Phosphocholination of target proteins also impairs accessibility to GTPase effector LepB. Can act on both GDP-bound and GTP-bound Rab proteins. | Hypothetical protein. | 0.761 |
legA8 | lpg1938 | lpg0695 | lpg1938 | Ankyrin repeat-containing protein; Virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). Acts as a phosphocholine transferase by mediating the addition of phosphocholine to Ser residues of host RAB1 (RAB1A, RAB1B or RAB1C) and RAB35, leading to displacement of GDP dissociation inhibitors (GDI). Phosphocholination of target proteins also impairs accessibility to GTPase effector LepB. Can act on both GDP-bound and GTP-bound Rab proteins. | Coenzyme F390 synthetase. | 0.758 |
legA8 | lpg2423 | lpg0695 | lpg2423 | Ankyrin repeat-containing protein; Virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). Acts as a phosphocholine transferase by mediating the addition of phosphocholine to Ser residues of host RAB1 (RAB1A, RAB1B or RAB1C) and RAB35, leading to displacement of GDP dissociation inhibitors (GDI). Phosphocholination of target proteins also impairs accessibility to GTPase effector LepB. Can act on both GDP-bound and GTP-bound Rab proteins. | Hypothetical protein-transmembrane region and signal peptide prediction. | 0.732 |
legA8 | lpg2506 | lpg0695 | lpg2506 | Ankyrin repeat-containing protein; Virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). Acts as a phosphocholine transferase by mediating the addition of phosphocholine to Ser residues of host RAB1 (RAB1A, RAB1B or RAB1C) and RAB35, leading to displacement of GDP dissociation inhibitors (GDI). Phosphocholination of target proteins also impairs accessibility to GTPase effector LepB. Can act on both GDP-bound and GTP-bound Rab proteins. | Sensor histidine kinase/response regulator LuxN. | 0.754 |
legA8 | lpg2587 | lpg0695 | lpg2587 | Ankyrin repeat-containing protein; Virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). Acts as a phosphocholine transferase by mediating the addition of phosphocholine to Ser residues of host RAB1 (RAB1A, RAB1B or RAB1C) and RAB35, leading to displacement of GDP dissociation inhibitors (GDI). Phosphocholination of target proteins also impairs accessibility to GTPase effector LepB. Can act on both GDP-bound and GTP-bound Rab proteins. | Probable thermolabile hemolysin. | 0.729 |
legA8 | lpg2911 | lpg0695 | lpg2911 | Ankyrin repeat-containing protein; Virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). Acts as a phosphocholine transferase by mediating the addition of phosphocholine to Ser residues of host RAB1 (RAB1A, RAB1B or RAB1C) and RAB35, leading to displacement of GDP dissociation inhibitors (GDI). Phosphocholination of target proteins also impairs accessibility to GTPase effector LepB. Can act on both GDP-bound and GTP-bound Rab proteins. | Serine carboxypeptidase. | 0.824 |
legA8 | pksJ | lpg0695 | lpg2186 | Ankyrin repeat-containing protein; Virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). Acts as a phosphocholine transferase by mediating the addition of phosphocholine to Ser residues of host RAB1 (RAB1A, RAB1B or RAB1C) and RAB35, leading to displacement of GDP dissociation inhibitors (GDI). Phosphocholination of target proteins also impairs accessibility to GTPase effector LepB. Can act on both GDP-bound and GTP-bound Rab proteins. | Polyketide synthase, type I. | 0.953 |
legA8 | yjeA | lpg0695 | lpg0712 | Ankyrin repeat-containing protein; Virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). Acts as a phosphocholine transferase by mediating the addition of phosphocholine to Ser residues of host RAB1 (RAB1A, RAB1B or RAB1C) and RAB35, leading to displacement of GDP dissociation inhibitors (GDI). Phosphocholination of target proteins also impairs accessibility to GTPase effector LepB. Can act on both GDP-bound and GTP-bound Rab proteins. | Endo-1,4-beta-xylanase-like. | 0.723 |
legS2 | dnaK | lpg2176 | lpg2025 | Sphingosine-1-phosphate lyase I; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine (By similarity). Possibly implicated in influencing the macrophage autophagy pathway. | Chaperone protein DnaK, heat shock protein Hsp70; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.825 |
legS2 | legA8 | lpg2176 | lpg0695 | Sphingosine-1-phosphate lyase I; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine (By similarity). Possibly implicated in influencing the macrophage autophagy pathway. | Ankyrin repeat-containing protein; Virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). Acts as a phosphocholine transferase by mediating the addition of phosphocholine to Ser residues of host RAB1 (RAB1A, RAB1B or RAB1C) and RAB35, leading to displacement of GDP dissociation inhibitors (GDI). Phosphocholination of target proteins also impairs accessibility to GTPase effector LepB. Can act on both GDP-bound and GTP-bound Rab proteins. | 0.743 |
legS2 | lpg1938 | lpg2176 | lpg1938 | Sphingosine-1-phosphate lyase I; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine (By similarity). Possibly implicated in influencing the macrophage autophagy pathway. | Coenzyme F390 synthetase. | 0.555 |
legS2 | lpg2506 | lpg2176 | lpg2506 | Sphingosine-1-phosphate lyase I; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine (By similarity). Possibly implicated in influencing the macrophage autophagy pathway. | Sensor histidine kinase/response regulator LuxN. | 0.458 |
legS2 | lpg2911 | lpg2176 | lpg2911 | Sphingosine-1-phosphate lyase I; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine (By similarity). Possibly implicated in influencing the macrophage autophagy pathway. | Serine carboxypeptidase. | 0.777 |