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sqdB-2 sqdB-2 gltA gltA fumC fumC idh idh pckG pckG SSO2869 SSO2869 gap gap aspB-2 aspB-2 sucD sucD sdhB sdhB ppcA ppcA
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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sqdB-2L-lactate dehydrogenase (sqdB); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. (327 aa)    
Predicted Functional Partners:
gltA
Citrate synthase; Energy Metabolism; Belongs to the citrate synthase family.
  
 0.999
fumC
Fumarate hydratase classe II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
 
 0.993
idh
Isocitrate dehydrogenase, probable (idh); Energy Metabolism, Tri-Carboxylic Acid Cycle.
  
 
 0.982
pckG
Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
    
 0.976
SSO2869
NAD-dependent malic enzyme (malate oxidoreductase); Energy Metabolism.
  
 0.972
gap
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (gap); Can use both NAD and NADP as cofactors, but exhibits a marked preference for NADP; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
  
 
 0.953
aspB-2
Aspartate aminotransferase (aspB-2); Amino Acid Biosynthesis, Aspartate.
  
 0.941
sucD
Succinyl-CoA synthetase, alpha subunit (sucD); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 
 0.926
sdhB
Succinate dehydrogenase subunit B (sdhB); Iron-sulfur subunit B; Energy Metabolism, Electron transport.
  
 
 0.925
ppcA
Conserved hypothetical protein; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family.
     
 0.924
Your Current Organism:
Saccharolobus solfataricus
NCBI taxonomy Id: 273057
Other names: S. solfataricus P2, Saccharolobus solfataricus P2, Sulfolobus solfataricus P2
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