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PyrF PyrF PyrE PyrE PyrR PyrR PyrB PyrB PyrD PyrD PyrC PyrC CarB CarB Upp Upp CarA CarA PyrH PyrH UbiB4 UbiB4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
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[Homology]
Score
PyrFOrotidine-5-phosphate decarboxylase; Best Blastp hit = gi|7107278|gb|AAF36353.1|AF187997_1 (AF187997) orotidine-5'-monophosphate decarboxylase [Halobacterium salinarum] gi|10581143|gb|AAG19923.1| (AE005076) orotidine-5'-monophosphate (Ura3); PyrF [Halobacterium sp. NRC-1], score 148, E-value 8.00E-35; Belongs to the OMP decarboxylase family. Type 2 subfamily. (316 aa)    
Predicted Functional Partners:
PyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
 
 0.999
PyrR
Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
  
 
 0.997
PyrB
Aspartate carbamoyltransferase, catalytic chain; Best Blastp hit = gi|13470872|ref|NP_102441.1| aspartate carbamoyltransferase [Mesorhizobium loti] gi|14021615|dbj|BAB48227.1| (AP002995) aspartate carbamoyltransferase [Mesorhizobium loti], score 293, E-value 3.00E-78; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
  
 0.992
PyrD
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
  
  
 0.991
PyrC
Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
 
  
 0.973
CarB
Carbamoylphosphate synthase large subunit (split gene in MJ); Best Blastp hit = gi|1168772|sp|P46537|CARB_BACCL 'CARBAMOYL-PHOSPHATE SYNTHASE, PYRIMIDINE-SPECIFIC, LARGE CHAIN (CARBAMOYL-PHOSPHATE SYNTHETASE AMMONIA CHAIN)' gi|2118367|pir||I40169 carbamoyl-phosphate synthase (glutamine-hydrolyzing) (EC 6.3.5.5) - Bacillus caldolyticus gi|312443|emb|CAA51739.1| (X73308) carbamoyl-phosphate synthase (glutamine-hydrolysing) [Bacillus caldolyticus], score 1146, E-value 0.
  
 0.971
Upp
Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.
  
 
 0.966
CarA
Carbamoylphosphate synthase small subunit; Best Blastp hit = gi|1705597|sp|P52557|CARA_BACCL 'CARBAMOYL-PHOSPHATE SYNTHASE, PYRIMIDINE-SPECIFIC, SMALL CHAIN (CARBAMOYL-PHOSPHATE SYNTHETASE GLUTAMINE CHAIN)' gi|2126769|pir||I40168 carbamoyl-phosphate synthase (glutamine-hydrolyzing) (EC 6.3.5.5) - Bacillus caldolyticus gi|312442|emb|CAA51738.1| (X73308) carbamoyl-phosphate synthase (glutamine-hydrolysing) [Bacillus caldolyticus], score 381, E-value 1.00E-105; Belongs to the CarA family.
 
  
 0.947
PyrH
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
   
 
 0.945
UbiB4
2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).
  
  
 0.933
Your Current Organism:
Caldanaerobacter subterraneus
NCBI taxonomy Id: 273068
Other names: C. subterraneus subsp. tengcongensis MB4, Caldanaerobacter subterraneus subsp. tengcongensis MB4, Thermoanaerobacter tengcongensis MB4, Thermoanaerobacter tengcongensis str. MB4, Thermoanaerobacter tengcongensis strain MB4
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