node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Saro_2107 | Saro_2681 | Saro_2107 | Saro_2681 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | tRNA synthetase, class II (G, H, P and S). | 0.887 |
Saro_2107 | hisA | Saro_2107 | Saro_1009 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.999 |
Saro_2107 | hisB | Saro_2107 | Saro_1006 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Imidazoleglycerol-phosphate dehydratase. | 0.981 |
Saro_2107 | hisC | Saro_2107 | Saro_0695 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Histidinol phosphate aminotransferase apoenzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.865 |
Saro_2107 | hisD | Saro_2107 | Saro_2920 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.981 |
Saro_2107 | hisE | Saro_2107 | Saro_1011 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | phosphoribosyl-ATP pyrophosphatase. | 0.999 |
Saro_2107 | hisF | Saro_2107 | Saro_1010 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.998 |
Saro_2107 | hisG | Saro_2107 | Saro_2919 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.977 |
Saro_2107 | hisH | Saro_2107 | Saro_1007 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.981 |
Saro_2681 | Saro_2107 | Saro_2681 | Saro_2107 | tRNA synthetase, class II (G, H, P and S). | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | 0.887 |
Saro_2681 | hisA | Saro_2681 | Saro_1009 | tRNA synthetase, class II (G, H, P and S). | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.907 |
Saro_2681 | hisB | Saro_2681 | Saro_1006 | tRNA synthetase, class II (G, H, P and S). | Imidazoleglycerol-phosphate dehydratase. | 0.905 |
Saro_2681 | hisC | Saro_2681 | Saro_0695 | tRNA synthetase, class II (G, H, P and S). | Histidinol phosphate aminotransferase apoenzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.613 |
Saro_2681 | hisD | Saro_2681 | Saro_2920 | tRNA synthetase, class II (G, H, P and S). | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.901 |
Saro_2681 | hisE | Saro_2681 | Saro_1011 | tRNA synthetase, class II (G, H, P and S). | phosphoribosyl-ATP pyrophosphatase. | 0.988 |
Saro_2681 | hisF | Saro_2681 | Saro_1010 | tRNA synthetase, class II (G, H, P and S). | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.916 |
Saro_2681 | hisG | Saro_2681 | Saro_2919 | tRNA synthetase, class II (G, H, P and S). | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.999 |
Saro_2681 | hisH | Saro_2681 | Saro_1007 | tRNA synthetase, class II (G, H, P and S). | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.882 |
guaA | hisA | Saro_0550 | Saro_1009 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.742 |
guaA | hisF | Saro_0550 | Saro_1010 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.501 |