node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Lxx13110 | ilvE | Lxx13110 | Lxx13120 | Oxidoreductase; Identified by sequence similarity. | Branched-chain amino acid aminotransferase; Identified by sequence similarity. | 0.462 |
Lxx13110 | panB | Lxx13110 | Lxx10000 | Oxidoreductase; Identified by sequence similarity. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.908 |
Lxx13110 | panC | Lxx13110 | Lxx21410 | Oxidoreductase; Identified by sequence similarity. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.910 |
Lxx13110 | panE | Lxx13110 | Lxx07200 | Oxidoreductase; Identified by sequence similarity. | 2-dehydropantoate 2-reductase; Identified by sequence similarity. | 0.919 |
ftsH | panB | Lxx21500 | Lxx10000 | Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.658 |
ftsH | panC | Lxx21500 | Lxx21410 | Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.500 |
glnA | glnE | Lxx10010 | Lxx10020 | Glutamine synthetase; Identified by sequence similarity; Belongs to the glutamine synthetase family. | Glutamine synthetase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transducti [...] | 0.947 |
glnA | panB | Lxx10010 | Lxx10000 | Glutamine synthetase; Identified by sequence similarity; Belongs to the glutamine synthetase family. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.688 |
glnE | glnA | Lxx10020 | Lxx10010 | Glutamine synthetase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transducti [...] | Glutamine synthetase; Identified by sequence similarity; Belongs to the glutamine synthetase family. | 0.947 |
glnE | panB | Lxx10020 | Lxx10000 | Glutamine synthetase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transducti [...] | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.629 |
ilvD | ilvE | Lxx13210 | Lxx13120 | Dihydroxy-acid dehydratase protein; Identified by sequence similarity; Belongs to the IlvD/Edd family. | Branched-chain amino acid aminotransferase; Identified by sequence similarity. | 0.991 |
ilvD | panB | Lxx13210 | Lxx10000 | Dihydroxy-acid dehydratase protein; Identified by sequence similarity; Belongs to the IlvD/Edd family. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.924 |
ilvE | Lxx13110 | Lxx13120 | Lxx13110 | Branched-chain amino acid aminotransferase; Identified by sequence similarity. | Oxidoreductase; Identified by sequence similarity. | 0.462 |
ilvE | ilvD | Lxx13120 | Lxx13210 | Branched-chain amino acid aminotransferase; Identified by sequence similarity. | Dihydroxy-acid dehydratase protein; Identified by sequence similarity; Belongs to the IlvD/Edd family. | 0.991 |
ilvE | panB | Lxx13120 | Lxx10000 | Branched-chain amino acid aminotransferase; Identified by sequence similarity. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.909 |
nadC | panB | Lxx16510 | Lxx10000 | Nicotinate-nucleotide pyrophosphorylase (carboxylating); Identified by sequence similarity; Belongs to the NadC/ModD family. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.619 |
nadC | panC | Lxx16510 | Lxx21410 | Nicotinate-nucleotide pyrophosphorylase (carboxylating); Identified by sequence similarity; Belongs to the NadC/ModD family. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.422 |
panB | Lxx13110 | Lxx10000 | Lxx13110 | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | Oxidoreductase; Identified by sequence similarity. | 0.908 |
panB | ftsH | Lxx10000 | Lxx21500 | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.658 |
panB | glnA | Lxx10000 | Lxx10010 | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | Glutamine synthetase; Identified by sequence similarity; Belongs to the glutamine synthetase family. | 0.688 |