STRINGSTRING
bioB bioB bioD bioD bioA bioA birA birA Clim_2429 Clim_2429 bioC bioC Clim_1451 Clim_1451 Clim_2428 Clim_2428 Clim_0485 Clim_0485 Clim_2152 Clim_2152 Clim_2424 Clim_2424
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (336 aa)    
Predicted Functional Partners:
bioD
Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
 
 
 0.998
bioA
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
  
 0.992
birA
biotin/acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
  
 
 0.985
Clim_2429
8-amino-7-oxononanoate synthase; PFAM: aminotransferase class I and II; KEGG: cph:Cpha266_0113 8-amino-7-oxononanoate synthase.
  
 0.949
bioC
Biotin biosynthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.
 
     0.910
Clim_1451
KEGG: cph:Cpha266_1913 hypothetical protein.
     
  0.900
Clim_2428
PFAM: protein of unknown function DUF452; KEGG: cph:Cpha266_0114 protein of unknown function DUF452.
 
     0.896
Clim_0485
Aminotransferase class I and II; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class I and II; KEGG: cph:Cpha266_1956 hypothetical protein.
 
  
 0.711
Clim_2152
8-amino-7-oxononanoate synthase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class I and II; aminotransferase class-III; KEGG: cph:Cpha266_2306 8-amino-7-oxononanoate synthase.
  
 0.646
Clim_2424
PFAM: AMP-dependent synthetase and ligase; KEGG: cph:Cpha266_2588 AMP-dependent synthetase and ligase.
  
    0.570
Your Current Organism:
Chlorobium limicola
NCBI taxonomy Id: 290315
Other names: C. limicola DSM 245, Chlorobium limicola 6330, Chlorobium limicola DSM 245, Chlorobium limicola DSMZ 245(T), Chlorobium limicola str. DSM 245, Chlorobium limicola strain DSM 245
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.