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hisC hisC hisB hisB hisH hisH hisD hisD hisA hisA AAur_1673 AAur_1673 hisG hisG hisF hisF AAur_2645 AAur_2645 pheA pheA AAur_4045 AAur_4045
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
hisCHistidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (372 aa)    
Predicted Functional Partners:
hisB
Imidazoleglycerol-phosphate dehydratase (IGPD); Identified by match to protein family HMM PF00475.
 
 0.999
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.997
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.997
hisA
Bifunctional HisA/TrpF protein; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR01919.
 
  
 0.980
AAur_1673
Prephenate dehydrogenase; Identified by match to protein family HMM PF02153.
 
 
 0.973
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
  
 0.959
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
  
 0.947
AAur_2645
Putative histidinol-phosphate phosphatase, inositol monophosphatase family; Identified by match to protein family HMM PF00459; match to protein family HMM TIGR02067.
 
 
 0.933
pheA
Prephenate dehydratase; Identified by match to protein family HMM PF00800; match to protein family HMM PF01842.
 
 
 0.927
AAur_4045
Putative 4-hydroxyphenylpyruvate dioxygenase; Identified by match to protein family HMM PF01261.
    
 0.921
Your Current Organism:
Paenarthrobacter aurescens
NCBI taxonomy Id: 290340
Other names: Arthrobacter aurescens TC1, P. aurescens TC1, Paenarthrobacter aurescens TC1
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