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hemL hemL Arth_2765 Arth_2765 hemA hemA hemC hemC Arth_2766 Arth_2766 hemE hemE hemH hemH Arth_3111 Arth_3111 Arth_3098 Arth_3098 Arth_2769 Arth_2769 Arth_2771 Arth_2771
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
hemLTIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase, class I and II; aminotransferase class-III; KEGG: lxx:Lxx01130 glutamate-1-semialdehyde 2,1-aminomutase. (447 aa)    
Predicted Functional Partners:
Arth_2765
Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: sco:SCO3311 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 
 0.999
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.996
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
  
 0.985
Arth_2766
uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
  
 0.950
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
  
 0.921
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.886
Arth_3111
TIGRFAM: uroporphyrin-III C-methyltransferase; siroheme synthase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: tfu:Tfu_2221 uroporphyrin-III C-methyltransferase, C-terminal:siroheme synthase, N-terminal.
 
   
 0.861
Arth_3098
TIGRFAM: amino acid adenylation domain; PFAM: AMP-dependent synthetase and ligase; Thioesterase; condensation domain protein; phosphopantetheine-binding; KEGG: fra:Francci3_2459 amino acid adenylation.
  
 
 0.841
Arth_2769
PFAM: Chlorite dismutase; KEGG: sco:SCO6042 hypothetical protein.
 
  
 0.837
Arth_2771
TIGRFAM: protoporphyrinogen oxidase; PFAM: FAD dependent oxidoreductase; KEGG: lxx:Lxx01060 protoporphyrinogen oxidase.
 
  
 0.820
Your Current Organism:
Arthrobacter sp. FB24
NCBI taxonomy Id: 290399
Other names: A. sp. FB24
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